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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update
PLoS ONE, Volume 4, No. 3, Article e4724, Year 2009
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Description
Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines and provide feedback on the success of HIV-1 treatment and prevention programs. To accurately compare transmitted drug resistance rates across geographic regions and times, the World Health Organization has recommended the adoption of a consensus genotypic definition of transmitted HIV-1 drug resistance. In January 2007, we outlined criteria for developing a list of mutations for drug-resistance surveillance and compiled a list of 80 RT and protease mutations meeting these criteria (surveillance drug resistance mutations; SDRMs). Since January 2007, several new drugs have been approved and several new drug-resistance mutations have been identified. In this paper, we follow the same procedures described previously to develop an updated list of SDRMs that are likely to be useful for ongoing and future studies of transmitted drug resistance. The updated SDRM list has 93 mutations including 34 NRTI-resistance mutations at 15 RT positions, 19 NNRTI-resistance mutations at 10 RT positions, and 40 PI-resistance mutations at 18 protease positions. © 2009 Bennett et al.
Authors & Co-Authors
Bennett, Diane E.
Switzerland, Geneva
Organisation Mondiale de la Santé
Camacho, Ricardo Jorge
Portugal, Lisbon
Centro Hospitalar de Lisboa Ocidental
Oţelea, Dan
Unknown Affiliation
Kuritzkes, Daniel R.D.
United States, Boston
Harvard Medical School
Fleury, Hervè J.A.
France, Bordeaux
Laboratoire de Microbiologie Fondamentale et Pathogénicité
Heneine, Walid M.
United States, Atlanta
Centers for Disease Control and Prevention
Kantor, Rami
United States, Providence
Brown University
Jordan, Michael R.
United States, Boston
Tufts University School of Medicine
Schapiro, Jonathan M.
United States, Palo Alto
Stanford University
Vandamme, Anne Mieke
Belgium, Leuven
Ku Leuven
Sandstrom, P.
Canada, Ottawa
Public Health Agency of Canada
Boucher, Charles A.B.
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Utrecht
Universiteit Utrecht
Van De Vijver, D. A.M.C.
Netherlands, Rotterdam
Erasmus Mc
Rhee, Soo-yoon
United States, Palo Alto
Stanford University
Liu, Tommy Fulisma
United States, Palo Alto
Stanford University
Morris, Lynn G.
United Kingdom, London
University College London
Shafer, Robert William
United States, Palo Alto
Stanford University
Statistics
Citations: 797
Authors: 17
Affiliations: 13
Identifiers
Doi:
10.1371/journal.pone.0004724
ISSN:
19326203
Research Areas
Infectious Diseases