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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
CD4 percentages and total lymphocyte counts as early surrogate markers for pediatric HIV-1 infection in resource-limited settings
Journal of Tropical Pediatrics, Volume 52, No. 5, Year 2006
Notification
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Description
The early diagnosis of pediatric HIV-1 infection is a critical issue in resource-limited settings to prioritize eligibility for antiretroviral therapy among HIV-1-infected children. A case-control study was performed within the ANRS 1201/1202 Ditrame Plus cohort (Abidjan, Côte d'Ivoire) to assess the usefulness of CD4+ T-cell percentage (CD4%) and total lymphocyte count (TLC) measured early in life in African children born to HIV-1-infected mothers. Using plasma HIV-1 RNA testing at 4 weeks of life as gold standard, CD4% and TLC were determined at month 3 and 6 in all 33 children HIV-1-infected in utero or intrapartum/early postpartum (cases) born to mothers receiving peripartum antiretroviral prophylaxis. Controls were 66 HIV-1-uninfected children from the same cohort. At month 3, the median CD4% was significantly lower in HIV-1-infected children (17.7%, 95% percentiles, 7.1-27.4) than in uninfected controls (34.8%, 18.5-45.3) (P < 0.001). A comparable difference was also observed at month 6. At the same time points, no significant difference was measurable for TLCs. The best threshold differentiating HIV-infected and uninfected children at month 3 was 25% CD4M+. Compared to HIV-1 RNA results, sensitivity of this marker was 87.1% (95% confidence interval, 70.2-96.4) at month 3 and 88.9% (70.8-97.6) at month 6. Specificity was 78.3% (63.6-89.0) and 88.3% (77.4-95.2), respectively. Early CD4% measurement allows one to classify adequately the vast majority of exposed children according to their HIV status. CD4% should be further evaluated under field conditions for the diagnosis of pediatric HIV-1 infection and the monitoring of pediatric antiretroviral therapy. © 2006 Oxford University Press.
Authors & Co-Authors
Rouet, François
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Burkina Faso, Ouagadougou
Centre Muraz
Inwoley, André
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Ékouévi, Didier Koumavi
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
France, Paris
Inserm
Viho, Ida
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Becquet, Renaud
France, Paris
Inserm
Sakarovitch, Charlotte
France, Paris
Inserm
Béquet, Laurence
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Tonwe-Gold, Besigin
Cote D'ivoire, Abidjan
Mtct Plus Initiative
Chaix, Marie Laure
France, Paris
Université Paris Cité
Leroy, Valeriane
France, Paris
Inserm
Rouzioux, Christine
France, Paris
Université Paris Cité
Dabis, Franćois Ç.Ois
France, Paris
Inserm
Timité-Konan, Marguerite
Unknown Affiliation
Welffens-Ekra, Christiane
Unknown Affiliation
Amani-Bossé, Clarisse
Unknown Affiliation
Ayékoé, Ignace Adou
Unknown Affiliation
Bédikou, Gédéon
Unknown Affiliation
Coulibaly, Nacoumba
Unknown Affiliation
Danel, Christine
Unknown Affiliation
Fassinou, Patricia
Unknown Affiliation
Horo, Apollinaire Gninlgninrin
Unknown Affiliation
Likikouët, Ruffin
Unknown Affiliation
Toure, Hassan
Unknown Affiliation
Fian, P.
Unknown Affiliation
Fofana, O.
Unknown Affiliation
Kouaho, G.
Unknown Affiliation
Koffi, Joseph
Unknown Affiliation
Ménan, Hervé Eby
Unknown Affiliation
Ouassa, Timothée
Unknown Affiliation
Touré, Ramata
Unknown Affiliation
Allou, Gérard
Unknown Affiliation
Castetbon, Katia
Unknown Affiliation
Dequae-Merchadou, Laurence
Unknown Affiliation
Touchard, Dominique
Unknown Affiliation
Agbo, Hélène
Unknown Affiliation
Aka-Dago, Hortense
Unknown Affiliation
Brou, Hermann
Unknown Affiliation
Desgrées-du-Loû, Annabel
Unknown Affiliation
Sihé, Alphonse
Unknown Affiliation
Tijou-Traoré, Annick
Unknown Affiliation
Zanou, Benjamin
Unknown Affiliation
Blanche, Stéphane
Unknown Affiliation
Delfraissy, Jean François
Unknown Affiliation
Lepage, Philippe
Unknown Affiliation
Mandelbrot, Laurent
Unknown Affiliation
Salamon, Roger L.
Unknown Affiliation
Statistics
Citations: 46
Authors: 46
Affiliations: 5
Identifiers
Doi:
10.1093/tropej/fml024
ISSN:
01426338
e-ISSN:
14653664
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Case-Control Study
Study Locations
Ivory Coast