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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Swarm Learning for decentralized and confidential clinical machine learning
Nature, Volume 594, No. 7862, Year 2021
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Description
Fast and reliable detection of patients with severe and heterogeneous illnesses is a major goal of precision medicine1,2. Patients with leukaemia can be identified using machine learning on the basis of their blood transcriptomes3. However, there is an increasing divide between what is technically possible and what is allowed, because of privacy legislation4,5. Here, to facilitate the integration of any medical data from any data owner worldwide without violating privacy laws, we introduce Swarm Learning—a decentralized machine-learning approach that unites edge computing, blockchain-based peer-to-peer networking and coordination while maintaining confidentiality without the need for a central coordinator, thereby going beyond federated learning. To illustrate the feasibility of using Swarm Learning to develop disease classifiers using distributed data, we chose four use cases of heterogeneous diseases (COVID-19, tuberculosis, leukaemia and lung pathologies). With more than 16,400 blood transcriptomes derived from 127 clinical studies with non-uniform distributions of cases and controls and substantial study biases, as well as more than 95,000 chest X-ray images, we show that Swarm Learning classifiers outperform those developed at individual sites. In addition, Swarm Learning completely fulfils local confidentiality regulations by design. We believe that this approach will notably accelerate the introduction of precision medicine. © 2021, The Author(s).
Authors & Co-Authors
Pickkers, Peter P.
Netherlands, Nijmegen
Radboud University Medical Center
Aziz, Nasir Ahmad
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Germany, Bonn
Universität Bonn
Bitzer, Michael
Germany, Tubingen
Eberhard Karls Universität Tübingen
Ossowski, Stephan
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Tubingen
Ngs Competence Center Tübingen
Casadei, Nicolas L.P.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Tubingen
Ngs Competence Center Tübingen
Herr, Christian
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Lehmann, Clara
Germany, Koln
Universität zu Köln
Germany, Koln
Partner Site Bonn-cologne
Augustin, Max
Germany, Koln
Universität zu Köln
Germany, Koln
Partner Site Bonn-cologne
Rybniker, Jan
Germany, Koln
Universität zu Köln
Germany, Koln
Partner Site Bonn-cologne
Altmüller, Janine
Germany, Koln
Universität zu Köln
Desai, Milind Y.
United States, Palo Alto
Hewlett Packard Enterprise
Heyckendorf, Jan
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Schreiber, Stefan W.
Germany, Kiel
Universitätsklinikum Schleswig-holstein Campus Kiel
Eggermann, Thomas
Germany, Aachen
Rheinisch-westfälische Technische Hochschule Aachen
Boor, Peter
Germany, Aachen
Uniklinik Rwth Aachen
Stingl, Julia Carolin
Germany, Aachen
Uniklinik Rwth Aachen
Röhrig, Rainer
Germany, Aachen
Uniklinik Rwth Aachen
Marx, Gernot
Germany, Aachen
Uniklinik Rwth Aachen
Dreher, Michael
Germany, Aachen
Uniklinik Rwth Aachen
Marx, Nikolaus
Germany, Aachen
Uniklinik Rwth Aachen
Nattermann, Jacob K.
Germany, Bonn
Universitätsklinikum Bonn
Germany, Braunschweig
Helmholtz Centre for Infection Research Hzi
Skowasch, Dirk
Germany, Bonn
Universität Bonn
Kurth, Ingo
Germany, Aachen
Rheinisch-westfälische Technische Hochschule Aachen
Keller, Andreas C.
Germany, Saarbrucken
Universität Des Saarlandes
United States, Palo Alto
Stanford University
Bals, Robert
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Nurnberg, Peter N.
Germany, Koln
Universität zu Köln
Riess, Olaf H.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Tubingen
Ngs Competence Center Tübingen
Rosenstiel, Philip C.
Germany, Kiel
Universitätsklinikum Schleswig-holstein Campus Kiel
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Germany, Bonn
Universität Bonn
Theis, Fabian J.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Aschenbrenner, Anna C.
Germany, Bonn
Universität Bonn
Netherlands, Nijmegen
Radboud University Medical Center
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Ulas, Thomas
Germany, Bonn
Universität Bonn
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Angelov, Angel
Germany, Tubingen
Ngs Competence Center Tübingen
Germany, Tubingen
Eberhard Karls Universität Tübingen
Becker, Anke
Germany, Marburg
Philipps-universität Marburg
Bezdan, Daniela
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Tubingen
Ngs Competence Center Tübingen
Bonifacio, Ezio E.
Germany, Dresden
Zentrum Für Regenerative Therapien Dresden
Bork, Peer
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Blum, Helmut
Germany, Munich
Ludwig-maximilians-universität München
Clavel, Thomas
Germany, Aachen
Rheinisch-westfälische Technische Hochschule Aachen
Cornberg, Markus
Germany, Hannover
Hannover Medical School
Germany, Hannover
Centre for Individualised Infection Medicine
Germany, Hannover
German Center for Infection Research Dzif
De La Rosa-Velazquez, Inti Alberto
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Diefenbach, Andreas
Germany, Berlin
Charité – Universitätsmedizin Berlin
Dilthey, Alexander T.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Fischer, Nicole
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Förstner, Konrad U.
Unknown Affiliation
Ganzenmueller, Tina
Germany, Tubingen
Eberhard Karls Universität Tübingen
Goesmann, Alexander
Germany, Giessen
Justus-liebig-universität Gießen
Göpel, Siri
Germany, Tubingen
Eberhard Karls Universität Tübingen
Grundhoff, Adam T.
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Grundmann, Hajo J.
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Hain, Torsten
Germany, Giessen
Justus-liebig-universität Gießen
Hanses, Frank
Germany, Regensburg
Klinikum Der Universität Regensburg Und Medizinische Fakultät
Hehr, Ute
Unknown Affiliation
Hoeper, Marius M.
Germany, Hannover
Hannover Medical School
Hübschmann, Daniel
Germany, Heidelberg
German Cancer Research Center
Hummel, Michael
Germany, Berlin
Charité – Universitätsmedizin Berlin
Iftner, Thomas
Germany, Tubingen
Eberhard Karls Universität Tübingen
Illig, Thomas
Germany, Hannover
Hannover Medical School
Janssen, Stefan
Germany, Giessen
Justus-liebig-universität Gießen
Kalinowski, Jörn
Germany, Bielefeld
Universität Bielefeld
Kallies, René
Germany, Leipzig
Helmholtz Zentrum Für Umweltforschung
Keppler, Oliver Till
Germany, Munich
Ludwig-maximilians-universität München
Germany, Munich
German Center for Infection Research Dzif
Klein, Christoph A.
Germany, Munich
Klinikum Der Universität München
Korbel, Jan O.
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kühnert, Denise
Germany, Jena
Max-planck-institut Für Menschheitsgeschichte
Li, Yang
Germany, Hannover
Hannover Medical School
Ludwig, Kerstin Urte
Germany, Bonn
Universität Bonn
Makarewicz, Oliwia
Unknown Affiliation
Marz, Manja
Germany, Jena
Michael Stifel Center Jena
Germany, Jena
Friedrich-schiller-universität Jena
McHardy, Alice Carolyn
Germany, Braunschweig
Helmholtz Centre for Infection Research Hzi
Nahnsen, Sven
Germany, Tubingen
Ngs Competence Center Tübingen
Germany, Tubingen
Eberhard Karls Universität Tübingen
Nöthen, Markus Maria
Germany, Bonn
Universität Bonn
Ntoumi, Francine
Germany, Tubingen
Eberhard Karls Universität Tübingen
Overmann, Jörg
Germany, Braunschweig
Deutsche Sammlung Von Mikroorganismen Und Zellkulturen Gmbh
Peter, Silke
Germany, Tubingen
Ngs Competence Center Tübingen
Germany, Tubingen
Eberhard Karls Universität Tübingen
Pfeffer, Klaus
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Pink, Isabell
Germany, Hannover
Hannover Medical School
Protzer, Ulrike
Germany, Munich
Technische Universität München
Ralser, Markus
Germany, Berlin
Charité – Universitätsmedizin Berlin
Ripke, Stephan
Germany, Berlin
Charité – Universitätsmedizin Berlin
Rocha, Ulisses
Germany, Leipzig
Helmholtz Zentrum Für Umweltforschung
Scheithauer, Simone
Germany, Gottingen
Georg-august-universität Göttingen
Schmid-Burgk, Jonathan Leo
Germany, Bonn
Universität Bonn
Sczyrba, Alexander
Germany, Bielefeld
Universität Bielefeld
Singh, Yogesh
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Tubingen
Ngs Competence Center Tübingen
Sonnabend, Michael S.
Germany, Tubingen
Ngs Competence Center Tübingen
Germany, Tubingen
Eberhard Karls Universität Tübingen
Stegle, Oliver
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Germany, Heidelberg
German Cancer Research Center
Stoye, Jens
Germany, Bielefeld
Universität Bielefeld
Vehreschild, Jörg Janne
Germany, Koln
Partner Site Bonn-cologne
Germany, Koln
Universität zu Köln
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Velavan, Thirumalaisamy P.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Walker, Andreas
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Walter, Jörn E.
Germany, Saarbrucken
Universität Des Saarlandes
Wieczorek, Dagmar
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Ziebuhr, John
Germany, Giessen
Justus-liebig-universität Gießen
GIamarellos-Bourboulis, Evangelos J.
Greece, Athens
National and Kapodistrian University of Athens
Statistics
Citations: 315
Authors: 96
Affiliations: 54
Identifiers
Doi:
10.1038/s41586-021-03583-3
ISSN:
00280836
Research Areas
Covid
Health System And Policy