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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
GROWTH-STIMULATING FACTOR IN REGENERATING CANINE LIVER
The Lancet, Volume 313, No. 8108, Year 1979
Notification
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Description
Extracts from dog livers which had been regenerating for 24, 48, and 72 h after hepatectomy were infused for 6 h into the left portal vein of animals which had fresh portacaval shunts (Eck fistula) and which were killed 2 and 3 days later. The brief exposure to the 48-h and especially the 72-h regenerating liver extracts induced a delayed proliferative response predominantly in the left liver lobes, with a slight spillover effect to the right liver lobes but none to the kidney. The response reached its peak 3 days later. In the left but not the right liver lobes, both the 48-h and the 72-h regenerating liver extract reversed the atrophy ordinarily caused by Eck fistula in 3 days and partly prevented the ultrastructural hepatocyte deterioration characteristic of Eck fistula. The active liver extracts apparently contained a growth-control factor or factors which is (are) not insulin or glucagon. © 1979.
Authors & Co-Authors
Starzl, Thomas E.
United States
Va Medical Center
United Kingdom, London
Imperial College London
Terblanche, John T.
United States
Va Medical Center
United Kingdom, London
Imperial College London
Porter, Kendrick A.
United States
Va Medical Center
United Kingdom, London
Imperial College London
Statistics
Citations: 73
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/S0140-6736(79)90519-1
ISSN:
01406736