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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The CEPH consortium linkage map of human chromosome 11
Genomics, Volume 27, No. 1, Year 1995
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Description
The CEPH consortium framework map of chromosome 11 is presented. The map was generated from CEPH family DNAs with 181 probe/enzyme combinations contributed by 20 laboratories. Seventy-seven of the loci are defined by microsatellite polymorphisms that can be typed by the PCR. A total of 42 loci have been placed on the map with likelihood support of at least 1000:1. The female, male, and sex-average maps extend for 179.6, 110.8, and 145.3 cM, respectively. The largest interval on the sex-average map is less than 11 cM, and the average distance between uniquely placed loci is 4 cM. The genotypic data obtained for map construction have been used to identify the positions of crossovers on the chromosomes of CEPH family children, allowing the localization of new markers without computationally intensive likelihood models and providing a basis for efficient extension of the linkage map to higher resolution. © 1995 Academic Press. All rights reserved.
Authors & Co-Authors
Litt, M.
Unknown Affiliation
Kramer, P. L.
Unknown Affiliation
Kort, E.
Unknown Affiliation
Fain, Pamela R.
Unknown Affiliation
Cox, Simon
Unknown Affiliation
Root, D.
Unknown Affiliation
White, Raymond L.
Unknown Affiliation
Weissenbach, Jean S.
Unknown Affiliation
Donis-Keller, Helen
Unknown Affiliation
Gatti, Richard A.
Unknown Affiliation
Weber, James L.
Unknown Affiliation
Nakamura, Yusuke
Unknown Affiliation
Julier, Cécile
Unknown Affiliation
Hayashi, K.
Unknown Affiliation
Spurr, Nigel K.
Unknown Affiliation
Dean, Michael C.
Unknown Affiliation
Mandel, Jean Louis
Unknown Affiliation
Kidd, Kenneth K.
Unknown Affiliation
Kruse, Torben Arvid
Unknown Affiliation
Retief, Andries E.
Unknown Affiliation
Bale, Allen E.
Unknown Affiliation
Meo, T.
Unknown Affiliation
Vergnaud, Gilles
Unknown Affiliation
Warren, S.
Unknown Affiliation
Willard, Huntington F.
Unknown Affiliation
Statistics
Citations: 25
Authors: 25
Affiliations: 20
Identifiers
Doi:
10.1006/geno.1995.1011
ISSN:
08887543
e-ISSN:
10898646
Research Areas
Maternal And Child Health
Participants Gender
Male
Female