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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Antiviral activities of sulfated polysaccharides isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales)
Marine Drugs, Volume 9, No. 7, Year 2011
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Description
Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 μg/mL. In addition, polysaccharides were capable of inhibiting the in vitro replication of Herpes simplex virus type 1 (HSV-1) on Vero cells values of EC50 of 4.1 and 17.2 μg/mL, respectively. The adsorption step of HSV-1 to the host cell seems to be the specific target for polysaccharide action. While for HIV-1, these results suggest a direct inhibitory effect on HIV-1 replication by controlling the appearance of the new generations of virus and potential virucidal effect. The polysaccharides from S. coronopifolius (PSC) and B. thuyoides (PBT) were composed of galactose, 3,6-anhydrogalactose, uronics acids, sulfate in ratios of 33.1, 11.0, 7.7 and 24.0% (w/w) and 25.4, 16.0, 3.2, 7.6% (w/w), respectively. © 2011 by the authors; licensee MDPI.
Authors & Co-Authors
Rhimou, Bouhlal
France, Rennes
Université Européenne de Bretagne
Morocco, Tetouan
Université Abdelmalek Essaadi
Haslin, Camille
France, Aubagne
Centre de Vie Agora
Chermann, Jean Claude
France, Aubagne
Centre de Vie Agora
Colliec-Jouault, Sylvia
France, Plouzane
Ifremer Institut Francais de Recherche Pour L'exploitation de la Mer
Sinquin, Corinne
France, Plouzane
Ifremer Institut Francais de Recherche Pour L'exploitation de la Mer
Simon, Gaëlle
France, Rennes
Université Européenne de Bretagne
Cérantola, Stéphane
France, Rennes
Université Européenne de Bretagne
Riadi, Hassane
Morocco, Tetouan
Université Abdelmalek Essaadi
Bourgougnon, Nathalie
France, Rennes
Université Européenne de Bretagne
Statistics
Citations: 170
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.3390/md9071187
e-ISSN:
16603397
Research Areas
Environmental
Infectious Diseases
Study Locations
Morocco