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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Lack of detectable HIV-1-specific CD8
+
T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals
Journal of Infectious Diseases, Volume 203, No. 2, Year 2011
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Description
Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1-specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1-specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1-specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Addo, Marylyn Martina
Unknown Affiliation
Altfeld, Marcus A.
Unknown Affiliation
Brainard, Diana M.
Unknown Affiliation
Rathod, Almas
Unknown Affiliation
Piechocka-Trocha, Alicja
Unknown Affiliation
Fideli, Ülgen Semaye
Unknown Affiliation
Mulenga, Joseph
Unknown Affiliation
Shutes, Erin L.
Unknown Affiliation
Alvino, Donna Marie
Unknown Affiliation
Hunter, Eric
Unknown Affiliation
Allen, Susan A.
Unknown Affiliation
Walker, Bruce D.
Unknown Affiliation
Statistics
Citations: 18
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1093/infdis/jiq028
ISSN:
00221899
Research Areas
Infectious Diseases
Study Locations
Zambia