Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Nature Genetics, Volume 54, No. 5, Year 2022
Notification
URL copied to clipboard!
Description
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 × 10−9), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. © 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
Authors & Co-Authors
Mahajan, Anubha
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United States, San Francisco
Genentech, Inc
Spracklen, Cassandra N.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Amherst
University of Massachusetts Amherst
Zhang, Weihua
United Kingdom, London
Imperial College London
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
Ng, Maggie Chor Yin
United States, Nashville
Vanderbilt University Medical Center
United States, Winston Salem
Wake Forest University School of Medicine
Petty, Lauren E.
United States, Nashville
Vanderbilt University Medical Center
Rueger, Sina
Finland, Helsinki
Helsingin Yliopisto
United Kingdom, London
University College London
Kim, Young Jin
South Korea, Cheongju
Korea National Institute of Health
Horikoshi, Momoko
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Mercader, Josep Maria
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Taliun, Daniel
United States, Ann Arbor
University of Michigan, Ann Arbor
Kwak, Soo-heon
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
South Korea, Seoul
Seoul National University Hospital
Robertson, Neil R.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Rayner, Nigel William
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Hinxton
Wellcome Sanger Institute
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Loh, Marie Chiew Shia
United Kingdom, London
Imperial College London
Singapore, Singapore City
Nanyang Technological University
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Kim, Bongjo
South Korea, Cheongju
Korea National Institute of Health
Chiou, Joshua
United States, La Jolla
University of California, San Diego
United States, New York
Pfizer Inc.
Lin, Kuang
United Kingdom, Oxford
University of Oxford
Preuss, Michael H.
United States, New York
Icahn School of Medicine at Mount Sinai
Takeuchi, Fumihiko
Japan, Tokyo
National Center for Global Health and Medicine
Nano, Jana
Netherlands, Rotterdam
Erasmus Mc
Guo, Xiuqing
United States, Torrance
Harbor-ucla Medical Center
Nakatochi, Masahiro
Japan, Nagoya
Nagoya University Graduate School of Medicine
Scott, Robert A.
United Kingdom, Cambridge
University of Cambridge
Huerta-Chagoya, Alicia
Mexico, Mexico
Consejo Nacional de Humanidades, Ciencias y Tecnologías
Mexico, Mexico
Universidad Nacional Autónoma de México
Graff, Misa E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Chai, Jinfang
Singapore, Singapore City
National University Health System
Parra, Esteban J.
Canada, Toronto
University of Toronto
Yao, Jie
United States, Torrance
Harbor-ucla Medical Center
Bielak, Lawrence F.
United States, Ann Arbor
University of Michigan, Ann Arbor
Hai, Yang
United States, Torrance
Harbor-ucla Medical Center
Steinthórsdóttir, Valgerdur
United States, Thousand Oaks
Amgen Incorporated
Cook, James P.
United Kingdom, Liverpool
University of Liverpool
Kals, Mart
Estonia, Tartu
Tartu Ülikool
Grarup, Niels
Denmark, Copenhagen
Københavns Universitet
Schmidt, Ellen M.
United States, Ann Arbor
University of Michigan, Ann Arbor
Sofer, Tamar
United States, Cambridge
Harvard University
United States, Boston
Brigham and Women's Hospital
Wuttke, Matthias
Germany, Freiburg Im Breisgau
Universität Freiburg
Sarnowski, Chloé
United States, Boston
School of Public Health
United States, San Francisco
Environmental Sciences Associates
Gieger, Christian
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Trompet, Stella
Netherlands, Leiden
Leids Universitair Medisch Centrum
Long, Jirong
United States, Nashville
Vanderbilt University Medical Center
Sun, Meng
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Tong, Lin
United States, Chicago
The University of Chicago
Chen, Weimin
United States, Charlottesville
University of Virginia School of Medicine
Noordam, Raymond
Netherlands, Leiden
Leids Universitair Medisch Centrum
Tam, Claudia Ha Ting
Hong Kong, Hong Kong
Chinese University of Hong Kong
China, Shanghai
Shanghai Jiao Tong University
Joo, Yoonjung Yoonie
China, Shanghai
Shanghai Jiao Tong University
United States, Chicago
Northwestern University Feinberg School of Medicine
South Korea, Seoul
Korea University
Chen, Chien Hsiun
Taiwan, Nankang
Academia Sinica Taiwan
Raffield, Laura Marie
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Lecoeur, Cécile
France, Lille
Epigénomique Fonctionnelle et Physiologie Moléculaire du Diabète et Maladies Associées
France, Lille
Chu Lille
Prins, Bram Peter
United Kingdom, Hinxton
Wellcome Sanger Institute
Nicolas, Aude
United States, Bethesda
National Institutes of Health Nih
Yanek, Lisa R.
United States, Baltimore
Johns Hopkins School of Medicine
Chen, Guanjie
United States, Bethesda
National Institutes of Health Nih
Jensen, Richard A.
United States, Seattle
University of Washington
Tajuddin, Salman M.
United States, Bethesda
National Institutes of Health Nih
Kabagambe, Edmond Kato
United States, Nashville
Vanderbilt University Medical Center
United States, New Orleans
Ochsner Health
An, Ping
United States, St. Louis
Washington University School of Medicine in St. Louis
Xiang, Anny Hui
United States, Oakland
Kaiser Permanente
Cade, Brian E.
United States, Boston
Harvard Medical School
United States, Boston
Brigham and Women's Hospital
Adair, Linda S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Adeyemo, Adebowale A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United States, Bethesda
National Institutes of Health Nih
Aguilar Salinas, Carlos A.
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
Akiyama, Masato
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Japan, Fukuoka
Kyushu University
Anand, Sonia Savitri
Canada, Hamilton
Mcmaster University
Canada, Hamilton
Population Health Research Institute, Ontario
Bertoni, Alain G.
United States, Winston Salem
Wake Forest University School of Medicine
Bork-Jensen, Jette
Denmark, Copenhagen
Københavns Universitet
Brandslund, Ivan
Denmark, Odense
Syddansk Universitet
Denmark, Vejle
Sygehus Lillebælt - Vejle
Brody, Jennifer A.
United States, Seattle
University of Washington
Brummett, Chad
United States, Ann Arbor
University of Michigan Medical School
Buchanan, Thomas A.
United States, Los Angeles
Keck School of Medicine of Usc
Canouil, Mickaël
France, Lille
Epigénomique Fonctionnelle et Physiologie Moléculaire du Diabète et Maladies Associées
France, Lille
Chu Lille
Chan, Julianna Chung Ngor
Hong Kong, Hong Kong
Chinese University of Hong Kong
China, Shanghai
Shanghai Jiao Tong University
Chang, Liching
Taiwan, Nankang
Academia Sinica Taiwan
Chee, Miaoli
Singapore, Singapore City
Singapore National Eye Centre
Chen, Ji
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Exeter
University of Exeter
Chen, Shyh Huei
United States, Winston Salem
Wake Forest University School of Medicine
Chen, Yuantsong
Taiwan, Nankang
Academia Sinica Taiwan
Chen, Zhengming
United Kingdom, Oxford
University of Oxford
Chuang, Lee Ming
Taiwan, Taipei
National Taiwan University Hospital
Taiwan, Taipei
National Taiwan University
Cushman, Mary E.
United States, Burlington
The University of Vermont
de Silva, Hithanadura Janaka
Sri Lanka, Kelaniya
University of Kelaniya
Dedoussis, George V.Z.
Greece, Athens
Harokopio University of Athens
Dimitrov, Latchezar M.
United States, Winston Salem
Wake Forest University School of Medicine
Doumatey, Ayo Priscille
United States, Bethesda
National Institutes of Health Nih
Duan, Qing
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Eckardt, Kai Uwe
Germany, Berlin
Charité – Universitätsmedizin Berlin
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Evans, Daniel S.
United States, San Francisco
California Pacific Medical Center
Evans, Michele Kim
United States, Bethesda
National Institutes of Health Nih
Fischer, Krista
Estonia, Tartu
Tartu Ülikool
Floyd, James S.
United States, Seattle
University of Washington
Fornage, Myriam
United States, Houston
University of Texas Health Science Center at Houston
Franco, Oscar H.
Netherlands, Rotterdam
Erasmus Mc
Frayling, Tim M.
United Kingdom, Exeter
University of Exeter
Freedman, Barry I.
United States, Winston Salem
Wake Forest University School of Medicine
Fuchsberger, Christian
United States, Ann Arbor
University of Michigan, Ann Arbor
Italy, Bolzano
Eurac Research
Gerstein, Hertzel C.
Canada, Hamilton
Mcmaster University
Canada, Hamilton
Population Health Research Institute, Ontario
Giedraitis, Vilmantas
Sweden, Uppsala
Uppsala Universitet
González-Villalpando, Clicerio
Unknown Affiliation
Goodarzi, Mark O.
United States, Los Angeles
Cedars-sinai Medical Center
Gross, Myron D.
United States, Minneapolis
University of Minnesota Twin Cities
Guo, Yu
China, Beijing
Chinese Academy of Medical Sciences & Peking Union Medical College
Hackinger, Sophie
United Kingdom, Hinxton
Wellcome Sanger Institute
Han, Sohee
South Korea, Cheongju
Korea National Institute of Health
Hattersley, Andrew T.
United Kingdom, Exeter
University of Exeter
Herder, Christian
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Howard, Annie Green
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Hung, Yijen
Taiwan, Taipei
Triservice General Hospital Taiwan
Taiwan, Taipei
National Defense Medical Center Taiwan
Hwang, Mi-yeong
South Korea, Cheongju
Korea National Institute of Health
Hwu, Chii Min
Taiwan, Taipei
Taipei Veterans General Hospital
Taiwan, Hsinchu
National Yang Ming Chiao Tung University
Ichihara, Sahoko
Japan, Kawachi District
Jichi Medical University
Ikram, Mohammad Arfan
Netherlands, Rotterdam
Erasmus Mc
Ingelsson, Martin
Sweden, Uppsala
Uppsala Universitet
Islam, Md Tariqul
Bangladesh, Dhaka
Uchicago Research Bangladesh
Jang, Hye-mi
South Korea, Cheongju
Korea National Institute of Health
Jiang, Guozhi
Hong Kong, Hong Kong
Chinese University of Hong Kong
China, Shanghai
Shanghai Jiao Tong University
Jonas, Jost Bruno
Switzerland, Basel
Institute of Molecular and Clinical Ophthalmology Basel
Jørgensen, Marit E. Eika
Denmark, Herlev
Steno Diabetes Center Copenhagen
Denmark, Odense
Syddansk Universitet
Jörgensen, Torben J.
Denmark, Copenhagen
Frederiksberg Hospital
Denmark, Copenhagen
Københavns Universitet
Denmark, Aalborg
Aalborg University
Kamatani, Yoichiro
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Japan, Tokyo
The University of Tokyo
Kandeel, Fouad R.
United States, Duarte
City of Hope National Med Center
Kasturiratne, Anuradhani
Sri Lanka, Kelaniya
University of Kelaniya
Keaton, Jacob M.
United States, Winston Salem
Wake Forest University School of Medicine
United States, Nashville
Vanderbilt University Medical Center
United States, Bethesda
National Institutes of Health Nih
Kho, Abel Ngo
United States, Chicago
Northwestern University Feinberg School of Medicine
Khor, Chiea Chuen
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Kohara, Katsuhiko
Japan, Matsuyama
Ehime University
Kriebel, Jennifer
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Kronenberg, Florian
Austria, Innsbruck
Medizinische Universitat Innsbruck
Kuusisto, Johanna K.
Finland, Kuopio
Kuopio University Hospital
Läll, Kristi
Estonia, Tartu
Tartu Ülikool
Lange, Leslie A.
United States, Aurora
University of Colorado Anschutz Medical Campus
Mayol, Nanette L.
Philippines, Cebu
University of San Carlos
Leong, Aaron
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Li, Liming
China, Beijing
Peking University
Li, Yun
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Li-Gao, Ruifang
Netherlands, Leiden
Leids Universitair Medisch Centrum
Ligthart, Symen
Netherlands, Rotterdam
Erasmus Mc
Lindgren, Cecilia M.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United States, Cambridge
Broad Institute
United Kingdom, Oxford
University of Oxford
Linneberg, Allan R.
Denmark, Copenhagen
Frederiksberg Hospital
Denmark, Copenhagen
Københavns Universitet
Liu, Chingti
United States, Boston
School of Public Health
Locke, Adam E.
United States, St. Louis
Washington University School of Medicine in St. Louis
United States, Tarrytown
Regeneron Genetics Center
Louie, Tin L.
United States, Seattle
University of Washington
Luan, Jian'fan N.An
United Kingdom, Cambridge
University of Cambridge
Luk, Andrea On Yan
Hong Kong, Hong Kong
Chinese University of Hong Kong
China, Shanghai
Shanghai Jiao Tong University
Lyssenko, Valeriya
Sweden, Malmo
Lund University Diabetes Centre
Norway, Bergen
Universitetet I Bergen
Mamakou, Vasiliki
Greece, Athens
National and Kapodistrian University of Athens
Meitinger, Thomas A.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Technische Universität München
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Metspalu, Andres H.
Estonia, Tartu
Tartu Ülikool
Morris, Andrew D.
United Kingdom, Edinburgh
The University of Edinburgh
Nadkarni, Girish N.
United States, New York
Icahn School of Medicine at Mount Sinai
Germany, Potsdam
Universität Potsdam
Nalls, Mike A.
United States, Bethesda
National Institutes of Health Nih
United States, Glen Echo
Data Tecnica International
Nayak, Uma
United States, Charlottesville
University of Virginia School of Medicine
Nongmaithem, Suraj Singh
India, Hyderabad
Centre for Cellular and Molecular Biology India
Ntalla, Ioanna
United Kingdom, London
Queen Mary University of London
Okada, Yukinori
Japan, Suita
Graduate School of Medicine
Japan, Suita
Osaka University
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Orozco, Lorena S.
Mexico, Mexico
Instituto Nacional de Medicina Genómica
Patel, Sanjay R.
United States, Pittsburgh
University of Pittsburgh
Pereira, Mark A.
United States, Minneapolis
University of Minnesota Twin Cities
Peters, Annette Michael
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Pirie, Fraser J.
South Africa, Durban
College of Health Sciences
Prasad, Gauri
India, Ghaziabad
Academy of Scientific and Innovative Research Acsir
India, New Delhi
Council of Scientific and Industrial Research India
Rasmussen-Torvik, Laura J.
United States, Chicago
Northwestern University Feinberg School of Medicine
Reiner, Alexander Paul
United States, Seattle
Fred Hutchinson Cancer Center
Roden, M. W.
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Rohde, Rebecca R.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Sander, Maike
United States, La Jolla
University of California, San Diego
Sattar, Naveed A.
United Kingdom, Glasgow
University of Glasgow
Schönherr, Sebastian
Austria, Innsbruck
Medizinische Universitat Innsbruck
Schurmann, Claudia
United States, New York
Icahn School of Medicine at Mount Sinai
Germany, Potsdam
Universität Potsdam
Shriner, Daniel A.
United States, Bethesda
National Institutes of Health Nih
Smith, Jennifer Anne
United States, Ann Arbor
University of Michigan, Ann Arbor
So, Wingyee
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Hong Kong, Hong Kong
Chinese University of Hong Kong
Stančáková, Alena
Finland, Kuopio
Kuopio University Hospital
Stilp, Adrienne M.
United States, Seattle
University of Washington
Strauch, Konstantin
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Germany, Mainz
Johannes Gutenberg-universität Mainz
Takahashi, Atsushi
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Japan, Suita
National Cerebral and Cardiovascular Center
Taylor, Kent D.
United States, Torrance
Harbor-ucla Medical Center
Thorand, Barbara
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Thorleifsson, Gudmar
United States, Thousand Oaks
Amgen Incorporated
Thorsteinsdóttir, Unnur Arna
United States, Thousand Oaks
Amgen Incorporated
Iceland, Reykjavik
Reykjavík University
Tomlinson, Brian W.Y.
Hong Kong, Hong Kong
Chinese University of Hong Kong
Macao, Taipa
Macau University of Science and Technology
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Spain, Madrid
Escuela Nacional de Sanidad
Austria, Krems an Der Donau
Donau-universität Krems
Saudi Arabia, Jeddah
King Abdulaziz University
Udler, Miriam S.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
van Dam, Robertus Martinus
Singapore, Singapore City
National University Health System
van Klinken, Jan Bert
Netherlands, Leiden
Leids Universitair Medisch Centrum
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Varma, Rohit
United States, Los Angeles
Hollywood Presbyterian Medical Center
Vujkovic, Marijana
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Wheeler, Eleanor
United Kingdom, Cambridge
University of Cambridge
Whitsel, Eric A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Wickramasinghe, Ananda Rajitha
Sri Lanka, Kelaniya
University of Kelaniya
van Dijk, Ko Willems
Netherlands, Leiden
Leids Universitair Medisch Centrum
Witte, Daniel R.
Denmark, Aarhus
Aarhus Universitet
Denmark, Odense
Danish Diabetes Academy
Yajnik, Chittaranjan Sakerlal
India, Pune
Kem Hospital
Yengo, Loic
Australia, Brisbane
The University of Queensland
Yoon, Kyungheon
South Korea, Cheongju
Korea National Institute of Health
Yu, Canqing
China, Beijing
Peking University
Yuan, Jianmin
United States, Pittsburgh
University of Pittsburgh
Yusuf, Salim
Canada, Hamilton
Mcmaster University
Canada, Hamilton
Population Health Research Institute, Ontario
Zheng, Wei
United States, Nashville
Vanderbilt University Medical Center
Ipp, Eli
United States, Torrance
Harbor-ucla Medical Center
Redline, Susan S.
United States, Boston
Harvard Medical School
United States, Boston
Brigham and Women's Hospital
United States, Boston
Beth Israel Deaconess Medical Center
Cho, Yoon-shin
South Korea, Chuncheon
Hallym University
Lind, Lars L.
Sweden, Uppsala
Uppsala Universitet
Province, Michael A.
United States, St. Louis
Washington University School of Medicine in St. Louis
Hanis, Craig L.
United States, Houston
University of Texas Health Science Center at Houston
Peyser, Patricia A.
United States, Ann Arbor
University of Michigan, Ann Arbor
Ingelsson, Erik
United States, Stanford
Stanford University School of Medicine
Sweden, Solna
Science for Life Laboratory
Zonderman, Alan B.
United States, Bethesda
National Institutes of Health Nih
Psaty, Bruce M.
United States, Seattle
University of Washington
United States, Washington, D.c.
United States Department of Health and Human Services
Wang, Yaxing
China, Beijing
Capital Medical University
Rotimi, Charles N.
United States, Bethesda
National Institutes of Health Nih
Becker, Diane M.
United States, Baltimore
Johns Hopkins School of Medicine
Matsuda, Fumihiko
Japan, Kyoto
Graduate School of Medicine
Liu, Yongmei
United States, Winston Salem
Wake Forest University School of Medicine
United States, Durham
Duke University School of Medicine
Zeggini, Eleftheria
United Kingdom, Hinxton
Wellcome Sanger Institute
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Technische Universität München
Rich, Stephen S.
United States, Charlottesville
University of Virginia School of Medicine
Kooperberg, Charles L.
United States, Seattle
Fred Hutchinson Cancer Center
Pankow, Jim S.
United States, Minneapolis
University of Minnesota Twin Cities
Engert, James C.
Canada, Montreal
Université Mcgill
Chen, Yii Der Ida
United States, Torrance
Harbor-ucla Medical Center
Froguel, Philippe
France, Lille
Epigénomique Fonctionnelle et Physiologie Moléculaire du Diabète et Maladies Associées
France, Lille
Chu Lille
United Kingdom, London
Imperial College London
Wilson, James Gaines
United States, Jackson
University of Mississippi Medical Center
Sheu, Wayne Huey Herng
Taiwan, Taipei
National Defense Medical Center Taiwan
Taiwan, Hsinchu
National Yang Ming Chiao Tung University
Taiwan, Taichung
Veterans General Hospital-taichung Taiwan
Kardia, Sharon L.R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Wu, Jeryuarn
Taiwan, Nankang
Academia Sinica Taiwan
Hayes, Matthew Geoffrey
United States, Chicago
Northwestern University Feinberg School of Medicine
United States, Evanston
Northwestern University
Ma, Ronald Ching Wan
Hong Kong, Hong Kong
Chinese University of Hong Kong
China, Shanghai
Shanghai Jiao Tong University
Wong, Tienyin
Singapore, Singapore City
Singapore National Eye Centre
Singapore, Singapore City
Duke-nus Medical School
Singapore, Singapore City
National University Health System
Groop, Leif C.
Finland, Helsinki
Helsingin Yliopisto
Sweden, Malmo
Lund University Diabetes Centre
Mook-Kanamori, Dennis Owen
Netherlands, Leiden
Leids Universitair Medisch Centrum
Ratan Chandak, Giriraj Ratan
India, Hyderabad
Centre for Cellular and Molecular Biology India
Collins, Francis S.
United States, Bethesda
National Institutes of Health Nih
Bharadwaj, Dwaipayan
India, Ghaziabad
Academy of Scientific and Innovative Research Acsir
India, New Delhi
Jawaharlal Nehru University
Paré, Guillaume
Canada, Hamilton
Population Health Research Institute, Ontario
Canada, Hamilton
Mcmaster University
Ahsan, Habibul A.M.Nazmul
United States, Chicago
The University of Chicago
Motala, Ayesha A.
South Africa, Durban
College of Health Sciences
Shu, Xiaoou
United States, Nashville
Vanderbilt University Medical Center
Park, Kyong-soo
South Korea, Seoul
Seoul National University Hospital
South Korea, Seoul
Seoul National University College of Medicine
South Korea, Seoul
Seoul National University
Jukema, Johan Wouter
Netherlands, Leiden
Leids Universitair Medisch Centrum
Netherlands, Utrecht
Netherlands Heart Institute
McKean-Cowdin, Roberta
United States, Los Angeles
Keck School of Medicine of Usc
Grallert, Harald
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Böttinger, Erwin P.
United States, New York
Icahn School of Medicine at Mount Sinai
Germany, Potsdam
Universität Potsdam
Dehghan, Abbas
United Kingdom, London
Imperial College London
Netherlands, Rotterdam
Erasmus Mc
Tai, E. Shyong
Singapore, Singapore City
National University Health System
Singapore, Singapore City
Duke-nus Medical School
Dupuis, Josèe
United States, Boston
School of Public Health
Kato, Norihiro
Japan, Tokyo
National Center for Global Health and Medicine
Laakso, M. M.
Finland, Kuopio
Kuopio University Hospital
Köttgen, Anna
Germany, Freiburg Im Breisgau
Universität Freiburg
Koh, Woon Puay
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Singapore, Singapore City
National University of Singapore
Palmer, Colin Neil Alexander
United Kingdom, Dundee
University of Dundee
Liu, Simin
United States, Providence
Brown University
United States, Providence
The Warren Alpert Medical School
Abecasis, Gonçalo R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Kooner, Jaspal Singh
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
United Kingdom, London
Imperial College London
Loos, Ruth J.F.
United States, New York
Icahn School of Medicine at Mount Sinai
Denmark, Copenhagen
Københavns Universitet
North, Kari E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Haiman, Christopher A.
United States, Los Angeles
Keck School of Medicine of Usc
Florez, Jose C.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Saleheen, Danish
United States, Philadelphia
University of Pennsylvania
Pakistan, Karachi
Center for Non-communicable Diseases
Hansen, Torben
Denmark, Copenhagen
Københavns Universitet
Pedersen, Oluf Borbye
Denmark, Copenhagen
Københavns Universitet
Mägi, Reedik
Estonia, Tartu
Tartu Ülikool
Langenberg, Claudia C.
United Kingdom, Cambridge
University of Cambridge
Germany, Berlin
Charité – Universitätsmedizin Berlin
Wareham, Nicholas J.
United Kingdom, Cambridge
University of Cambridge
Kadowaki, Takashi
Japan, Tokyo
The University of Tokyo
Japan, Minato
Toranomon Hospital
Lee, Juyoung
South Korea, Cheongju
Korea National Institute of Health
Millwood, Iona Y.
United Kingdom, Oxford
University of Oxford
Stefánsson, Kari
United States, Thousand Oaks
Amgen Incorporated
Iceland, Reykjavik
Reykjavík University
Myers, Simon R.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
University of Oxford
Ferrer, Jorge P.
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Madrid
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas
United Kingdom, London
Imperial College London
Gaulton, Kyle J.
United States, La Jolla
University of California, San Diego
Meigs, James B.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Mohlke, Karen
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Gloyn, Anna L.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United States, Palo Alto
Stanford University
Bowden, Donald W.
United States, Winston Salem
Wake Forest University School of Medicine
Below, Jennifer E.
United States, Nashville
Vanderbilt University Medical Center
Chambers, John Campbell
United Kingdom, London
Imperial College London
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
Singapore, Singapore City
Nanyang Technological University
Sim, Xueling
Singapore, Singapore City
National University Health System
Boehnke, Michael L.
United States, Ann Arbor
University of Michigan, Ann Arbor
Rotter, Jerome I.
United States, Torrance
Harbor-ucla Medical Center
McCarthy, Mark I.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United States, San Francisco
Genentech, Inc
Morris, Andrew Paul
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Liverpool
University of Liverpool
Estonia, Tartu
Tartu Ülikool
United Kingdom, Manchester
The University of Manchester
United Kingdom, Manchester
Manchester University Nhs Foundation Trust
Statistics
Citations: 115
Authors: 281
Affiliations: 186
Identifiers
Doi:
10.1038/s41588-022-01058-3
ISSN:
10614036
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Systematic review