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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
The genome and life-stage specific transcriptomes of Globodera pallida elucidate key aspects of plant parasitism by a cyst nematode
Genome Biology, Volume 15, No. 3, Article R43, Year 2014
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Description
Background: Globodera pallida is a devastating pathogen of potato crops, making it one of the most economically important plant parasitic nematodes. It is also an important model for the biology of cyst nematodes. Cyst nematodes and root-knot nematodes are the two most important plant parasitic nematode groups and together represent a global threat to food security. Results: We present the complete genome sequence of G. pallida, together with transcriptomic data from most of the nematode life cycle, particularly focusing on the life cycle stages involved in root invasion and establishment of the biotrophic feeding site. Despite the relatively close phylogenetic relationship with root-knot nematodes, we describe a very different gene family content between the two groups and in particular extensive differences in the repertoire of effectors, including an enormous expansion of the SPRY domain protein family in G. pallida, which includes the SPRYSEC family of effectors. This highlights the distinct biology of cyst nematodes compared to the root-knot nematodes that were, until now, the only sedentary plant parasitic nematodes for which genome information was available. We also present in-depth descriptions of the repertoires of other genes likely to be important in understanding the unique biology of cyst nematodes and of potential drug targets and other targets for their control. Conclusions: The data and analyses we present will be central in exploiting post-genomic approaches in the development of much-needed novel strategies for the control of G. pallida and related pathogens. © 2014 Cotton et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Cotton, James A.
United Kingdom, Hinxton
Wellcome Sanger Institute
Lilley, Catherine J.
United Kingdom, Leeds
University of Leeds
Jones, Laura M.
United Kingdom, Leeds
University of Leeds
Kikuchi, Taisei
Japan, Tsukuba
Forestry and Forest Products Research Institute
Japan, Miyazaki
University of Miyazaki Faculty of Medicine
Reid, Adam James
United Kingdom, Hinxton
Wellcome Sanger Institute
Thorpe, Peter
United Kingdom, Leeds
University of Leeds
United Kingdom, Aberdeen
The James Hutton Institute
Tsai, Isheng Jason
United Kingdom, Hinxton
Wellcome Sanger Institute
Japan, Miyazaki
University of Miyazaki Faculty of Medicine
Taiwan, Taipei
Academia Sinica, Biodiversity Research Center
Beasley, Helen
United Kingdom, Hinxton
Wellcome Sanger Institute
Blok, Vivian Carol
United Kingdom, Aberdeen
The James Hutton Institute
Cock, Peter J.A.
United Kingdom, Aberdeen
The James Hutton Institute
den Akker, Sebastian Eves van
United Kingdom, Leeds
University of Leeds
United Kingdom, Aberdeen
The James Hutton Institute
Holroyd, Nancy
United Kingdom, Hinxton
Wellcome Sanger Institute
Hunt, Martin
United Kingdom, Hinxton
Wellcome Sanger Institute
Mantelin, Sophie
United Kingdom, Aberdeen
The James Hutton Institute
Naghra, Hardeep
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Nottingham
University of Nottingham
Pain, Arnab P.
United Kingdom, Hinxton
Wellcome Sanger Institute
Saudi Arabia, Thuwal
King Abdullah University of Science and Technology
Palomares-Rius, Juan Emilio
United Kingdom, Aberdeen
The James Hutton Institute
Spain, Cordoba
Csic - Instituto de Agricultura Sostenible Ias
Zarowiecki, Magdalena
United Kingdom, Hinxton
Wellcome Sanger Institute
Berriman, Matthew
United Kingdom, Hinxton
Wellcome Sanger Institute
Jones, John T.
United Kingdom, Aberdeen
The James Hutton Institute
Urwin, Peter E.
United Kingdom, Leeds
University of Leeds
Statistics
Citations: 21
Authors: 21
Affiliations: 9
Identifiers
Doi:
10.1186/gb-2014-15-3-r43
e-ISSN:
1474760X
Research Areas
Food Security
Genetics And Genomics
Study Approach
Qualitative