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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Epidemiological aspects of budd-chiari in Egyptian patients: A single-center study
World Journal of Gastroenterology, Volume 17, No. 42, Year 2011
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Description
AIM: To describe the socio-demographic features, etiology, and risk factors for Budd-Chiari syndrome (BCS) in Egyptian patients. METHODS: Ninety-four Egyptian patients with confirmed primary Budd-Chiari syndrome were presented to the Budd-Chiari Study Group (BCSG) and admitted to the Tropical Medicine Department of Ain Shams University Hospital (Cairo, Egypt). Complete clinical evaluation and laboratory investigations, including a thrombophilia workup and full radiological assessment, were performed to determine underlying disease etiologies. RESULTS: BCS was chronic in 79.8% of patients, acute or subacute in 19.1%, and fulminant in 1.1%. Factor V Leiden mutation (FVLM) was the most common etiological cause of disease (53.1%), followed by mutation of the gene encoding methylene tetrahydrofolate reductase (MTHFR) (51.6%). Current or recent hormonal treatment was documented in 15.5% of females, and BCS associated with pregnancy was present in 17.2% of females. Etiology could not be determined in 8.5% of patients. Males had significantly higher rates of MTHFR gene mutation and Behçet's disease, and females had significantly higher rates of secondary antiphospholipid antibody syndrome. A highly significant positive relationship was evident between the presence of Behçet's disease and inferior vena caval occlusion, either alone or combined with occlusion of the hepatic veins (P < 0.0001). CONCLUSION: FVLM is the most common disease etiology and MTHFR the second most common in Egyptian BCS patients. BCS etiology tends to vary with geographic region. © 2011 Baishideng. All rights reserved.
Authors & Co-Authors
Sakr, Mohamed Amin
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Barakat, Eman Mahmoud Fathy
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Abdelhakam, Sara M.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Dabbous, Hany M.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Yousuf, Said
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Shaker, Mohamed
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Eldorry, Ahmed K.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Statistics
Citations: 33
Authors: 7
Affiliations: 1
Identifiers
Doi:
10.3748/wjg.v17.i42.4704
ISSN:
10079327
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Locations
Egypt
Participants Gender
Female