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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Respiratory manifestations in HIV-infected children pre- and post-HAART in Abidjan, the Ivory Coast
Paediatric Respiratory Reviews, Volume 5, No. 4, Year 2004
Notification
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Description
Among children infected with human immunodeficiency virus (HIV), respiratory diseases are a frequent cause of morbidity and mortality. This review describes respiratory manifestations of paediatric HIV infection before and after the beginning of HAART in Abidjan, Ivory Coast. In an observational cohort, HIV infected children had quarterly clinical visits and a day-clinic available all week for ill children. CD4 and viral load were measured at baseline and every 6 months thereafter. All children with a CD4 percentage below 25% were prescribed daily cotrimoxazole prophylaxis. Ninety-eight children (of a total of 282) were recruited before HAART and treated during the follow-up, there were 56 boys and 42 girls, with a mean age of 6.2 years at inclusion. The mean percentage of CD4 before HAART was 8.7%. Twelve children had a history of pulmonary tuberculosis and five were on antituberculosis treatment at inclusion. Fifty-one per cent presented with abnormalities on chest X-ray at inclusion. Before initiation of HAART, respiratory manifestations represented 32.4% of morbidity events and the incidence for 100 child/months was 9.29 for URTI, 15.2 for bronchitis, 6.07 for LRTI, 0.71 for tuberculosis and 0.36 for Pneumocystis carinii. After the initiation of HAART, respiratory manifestations represented 40.9% of all morbidity events and the incidence for 100 child/months was 5.35 for URTI, 9.48 for bronchitis, 2.17 for LRTI and 0.16 for tuberculosis. During HAART treatment, the incidence of respiratory infections decreased dramatically compared to before the antiretroviral treatment. However, respiratory events still represented 40% of all events occurring following the start of HAART therapy. © 2004 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Kouakoussui, Alain
Cote D'ivoire, Abidjan
Pac-ci
Fassinou, Patricia
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Yopougon
Anaky, Marie France
Cote D'ivoire, Abidjan
Pac-ci
Elenga, Narcisse
Cote D'ivoire, Abidjan
Pac-ci
Laguide, Rockiath
Cote D'ivoire, Abidjan
Pac-ci
Wemin, Marie Louise
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Touré, Ramata
Cote D'ivoire, Abidjan
Cedres
Ménan, Hervé Eby
Cote D'ivoire, Abidjan
Cedres
Rouet, François
Cote D'ivoire, Abidjan
Cedres
Msellati, Philippe
France, Montpellier
Ird Centre de Montpellier
Cote D'ivoire, Abidjan
Représentation Ird
Statistics
Citations: 38
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.prrv.2004.07.008
ISSN:
15260542
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Ivory Coast
Participants Gender
Male
Female