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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Association of Schistosoma haematobium infection with protection against acute Plasmodium falciparum malaria in Malian children
American Journal of Tropical Medicine and Hygiene, Volume 73, No. 6, Year 2005
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Description
Plasmodium falciparum and Schistosoma haematobium are co-endemic parasitic diseases with worldwide distribution. Evidence suggests interactions occur between helminthic and malaria infections, although it is unclear whether this effect is beneficial or harmful to the host. Malian children 4-14 years of age with asymptomatic 5. haematobium infection (SP) (n = 338) were prospectively matched by age, sex, and residence to children without schistosomiasis (SN) (n = 338) who were cleared of occult intestinal parasites, and followed-up for one malaria transmission season (25 weeks). The time to the first clinical malaria infection, incidence of malaria episodes, and parasitemia were recorded. Age associated protection from malaria in children with schistosomiasis was observed. SP children (4-8 years of age) compared with SN children demonstrated delayed time to first clinical malaria infection (74 versus 59 days; P = 0.04), fewer numbers of malaria episodes (1.55 versus 1.81 infections; P = 0.03) and lower geometric mean parasite densities (6,359 versus 9,874 asexual forms/mm3; P = 0.07) at first infection. No association between schistosomiasis and P. falciparum malaria was observed in children 9-14 years of age. We conclude that underlying schistosomiasis is associated with protection against clinical falciparum malaria in an age-dependent manner. Copyright © 2005 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Lyke, Kirsten E.
United States, Baltimore
University of Maryland School of Medicine
Dicko, Alassane A.
Mali, Bamako
University of Bamako
Dabo, Abdoulaye
Mali, Bamako
University of Bamako
Sangaré, Lansana
Mali, Bamako
University of Bamako
Koné, Abdoulaye Kassoum
Mali, Bamako
University of Bamako
Coulibaly, Drissa M.
Mali, Bamako
University of Bamako
Guindo, Ando B.
Mali, Bamako
University of Bamako
Traoré, Karim
Mali, Bamako
University of Bamako
Daou, Modibo
Mali, Bamako
University of Bamako
Diarra, Issa M.
Mali, Bamako
University of Bamako
Sztein, Marcelo B.
United States, Baltimore
University of Maryland School of Medicine
Plowe, Christopher Vv
United States, Baltimore
University of Maryland School of Medicine
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako
Statistics
Citations: 146
Authors: 13
Affiliations: 2
Identifiers
Doi:
10.4269/ajtmh.2005.73.1124
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study