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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Metrics to assess the quantity of antibiotic use in the outpatient setting: A systematic review followed by an international multidisciplinary consensus procedure
Journal of Antimicrobial Chemotherapy, Volume 73, Year 2018
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Description
Background: The international Innovative Medicines Initiative (IMI) project DRIVE-AB (Driving Reinvestment in Research and Development and Responsible Antibiotic Use) aims to develop a global definition of 'responsible' antibiotic use. Objectives: To identify consensually validated quantity metrics for antibiotic use in the outpatient setting. Methods: First, outpatient quantity metrics (OQMs) were identified by a systematic search of literature and web sites published until 12 December 2014. Identified OQMs were evaluated by a multidisciplinary, international stakeholder panel using a RAND-modified Delphi procedure. Two online questionnaires and a face-to-face meeting between them were conducted to assess OQM relevance for measuring the quantity of antibiotic use on a nine-point Likert scale, to add comments or to propose new metrics. Results: A total of 597 articles were screened, 177 studies met criteria for full-text screening and 138 were finally included. Twenty different OQMs were identified and appraised by 23 stakeholders. During the first survey, 14 OQMs were excluded and 6 qualified for discussion. During the face-to-face meeting, 10 stakeholders retained five OQMs and suggestions were made considering context and combination of metrics. The final set of metrics included defined daily doses, treatments/courses and prescriptions per defined population, treatments/ courses and prescriptions per defined number of physician contacts and seasonal variation of total antibiotic use. Conclusions: A small set of consensually validated metrics to assess the quantity of antibiotic use in the outpatient setting was obtained, enabling (inter)national comparisons. The OQMs will help build a global conceptual framework for responsible antibiotic use. © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
Authors & Co-Authors
Versporten, Ann P.R.
Belgium, Antwerpen
Universiteit Antwerpen
Gyssens, I. C.
Netherlands, Nijmegen
Radboud University Medical Center
Belgium, Hasselt
Universiteit Hasselt
Pulcini, Céline
France, Nancy
Université de Lorraine
France, Nancy
Chu de Nancy
Monnier, Annelie A.
Netherlands, Nijmegen
Radboud University Medical Center
Belgium, Hasselt
Universiteit Hasselt
Netherlands, Nijmegen
Radboud Universiteit
Schouten, Jeroen A.
Netherlands, Nijmegen
Radboud Universiteit
Tebano, Gianpiero
France, Nancy
Université de Lorraine
Le Maréchal, Marion
France, Nancy
Université de Lorraine
Huttner, Benedikt David
Switzerland, Geneva
Université de Genève Faculté de Médecine
Vlahović-Palčevski, Vera V.
Croatia, Rijeka
Klinički Bolnički Centar Rijeka
Goossens, Herman J.
Belgium, Antwerpen
Universiteit Antwerpen
Hulscher, Marlies E.J.L.
Netherlands, Nijmegen
Radboud Universiteit
Beović, Bojana
Unknown Affiliation
Bavestrello, Luis
Unknown Affiliation
Drew, Richard H.
Unknown Affiliation
Fernandes, Prabhavathi B.
Unknown Affiliation
Findlay, David
Unknown Affiliation
Friedland, Ian R.
Unknown Affiliation
Gould, Ian Malcolm
Unknown Affiliation
Hicks, Lauri A.
Unknown Affiliation
Mcgeer, Allison J.
Unknown Affiliation
Okeke, Iruka N.
Unknown Affiliation
Poulakou, Garyphallia G.
Unknown Affiliation
Rex, John H.
Unknown Affiliation
Tängdén, Thomas
Unknown Affiliation
Stichele, Robert Vander
Unknown Affiliation
Verweij, Marcel F.
Unknown Affiliation
Wertheim, Heiman F.L.
Unknown Affiliation
Statistics
Citations: 27
Authors: 27
Affiliations: 8
Identifiers
Doi:
10.1093/jac/dky119
ISSN:
03057453
Research Areas
Cancer
Study Design
Cross Sectional Study
Study Approach
Quantitative
Systematic review