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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Activity of 7-methyljuglone in combination with antituberculous drugs against Mycobacterium tuberculosis
Phytomedicine, Volume 13, No. 9-10, Year 2006
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Description
The recent increase in the incidence of tuberculosis with the emergence of multidrug-resistant (MDR) cases has lead to the search for new drugs that are effective against MDR strains of Mycobacterium tuberculosis and can augment the potential of existing drugs against tuberculosis. In the present study, we investigated the activities of a naphthoquinone, 7-methyljuglone, isolated from the roots of Euclea natalensis alone and in combination with other antituberculous drugs against extracellular and intracellular M. tuberculosis. Combinations of 7-methyljuglone with isoniazid or rifampicin resulted in a four to six-fold reduction in the minimum inhibitory concentration of each compound. Fractional inhibitory concentration (FIC) indexes obtained were 0.2 and 0.5, respectively, for rifampicin and isoniazid, suggesting a synergistic interaction between 7-methyljuglone and these anti-TB drugs. The ability of 7-methyljuglone to enhance the activity of isoniazid and rifampicin against both extracellular and intracellular organisms suggests that 7-methyljuglone may serve as a promising compound for development as an anti-tuberculous agent. © 2006 Elsevier GmbH. All rights reserved.
Authors & Co-Authors
Bapela, Nchinya Bennedict
South Africa, Pretoria
University of Pretoria
Lall, Namrita
South Africa, Pretoria
University of Pretoria
Fourie, P. B.
South Africa, Tygerberg
South African Medical Research Council
Franzblau, Scott Gary
United States, Chicago
University of Illinois at Chicago
Van Rensburg, Constance Elizabeth Jansen
South Africa, Pretoria
University of Pretoria
Statistics
Citations: 57
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.phymed.2006.08.001
ISSN:
09447113
Research Areas
Infectious Diseases
Study Design
Cohort Study