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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Survival of neural progenitor from the subventricular zone of the adult rat after transplantation into the host spinal cord of the same strain of adult rat
Anatomical Science International, Volume 80, No. 4, Year 2005
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Description
The subventricular zone (SVZ) of the lateral ventricle of the mammalian forebrain is the major site in which neural progenitor cells (NPC) persist in the adult brain. The NPC are located beneath ventricular ependymal cells and have the capacity to self-renew and continuously produce neurons and glial cells. We have shown previously that neurospheres can be obtained from the brain of deceased adult rats and that neurosphere cells survive after transplantation into the spinal cord. In the present study we investigated whether fresh NPC from living adult rats can survive and be integrated into host tissues after transplantation into the adult rat spinal cord of the same strain. We used rats expressing transgenic green fluorescent protein (GFP) as a donor to identify the transplanted NPCs. The SVZ tissues were obtained from the striatal wall of the lateral ventricle of adult GFP-rats and were grafted into lesions of the spinal cord at the cervical level. Two to 3 weeks after grafting, NPC migrated through the host tissue 0.5-1 mm away from the implantation site, and were integrated into the white matter of the host spinal cord. Surviving NPC exhibited immunohistochemical phenotypes of astrocytes (glial fibrillary acidic protein), but not for neurons (-tubulin III) or oligodendrocytes (Rip; Hybridoma Bank, Iowa City, IA, USA). Thus, NPC from the SVZ of adult rats can survive and differentiate into at least astrocytes, which can then be integrated into host tissue after transplantation into spinal cord lesions in the adult rat. © 2005 Japanese Association of Anatomists.
Authors & Co-Authors
Mligiliche, Nurru Lameck
Japan, Kyoto
Graduate School of Medicine
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Qatar, Doha
Weill Cornell Medicine-qatar
Xu, Yi
Japan, Kyoto
Graduate School of Medicine
Matsumoto, Naoya
Japan, Kyoto
Graduate School of Medicine
Ide, Chizuka
Japan, Kyoto
Graduate School of Medicine
Japan, Ibaraki
Aino University
Statistics
Citations: 4
Authors: 4
Affiliations: 4
Identifiers
ISSN:
14476959