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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Detection of aneuploidy rate for chromosomes X, y and 8 by fluorescence in-situ hybridization in spermatozoa from patients with severe non-obstructive oligozoospermia
Journal of Assisted Reproduction and Genetics, Volume 28, No. 10, Year 2011
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Description
Purpose: To evaluate the frequency of sperm nuclei disomy for chromosomes 8, X, and Y in patients with severe non-obstructive oligozoospermia and to assess possible correlations between sperm nuclei aneuploidy and semen parameters or a particular clinical phenotype. Materials and methods: The sperm aneuploidy rate for chromosomes X, Y, and 8 were assessed in 16 infertile men with severe non-obstructive oligozoospermia and 7 healthy men with normal semen parameters. The frequency of sperm aneuploidy was compared between several patients groups according to their clinical and biological factors. Results: The total rate of chromosomally abnormal spermatozoa was significantly higher in patients with severe oligozoospermia compared to control group (P<0.001). A significant relationship was found between the age of patients, sperm concentration, and morphology and the mean rate of sex chromosomes disomy. In addition to the low sperm count (<5×10 6/ml), an elevated FSH level and an exposed to an elevated temperature are two major predictive factors leading to the production of higher numbers of chromosomally abnormal gametes. Conclusion: Patients with severe oligozoospermia, who are potential candidates for assisted reproduction technology, presented a high level of sex numerical chromosome abnormalities, and consequently are at high risk of chromosome abnormalities in their offspring. © 2011 Springer Science+Business Media, LLC.
Authors & Co-Authors
Mougou, S.
Tunisia, Sousse
University Teaching Hospital
Brahem, Sonia
Tunisia, Sousse
University Teaching Hospital
Kammoun, Molka
Tunisia, Sousse
University Teaching Hospital
Jerbi, Mehdi
Tunisia, Sousse
Medical Office of Gynaecology and Obstetrics
Elghèzal, Hatem M.
Tunisia, Sousse
University Teaching Hospital
Ajina, Mounir Zaouali
Tunisia, Sousse
University Teaching Hospital
Saâd, Ali
Tunisia, Sousse
University Teaching Hospital
Statistics
Citations: 24
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1007/s10815-011-9621-x
ISSN:
10580468
Research Areas
Genetics And Genomics
Study Design
Randomised Control Trial
Participants Gender
Male