Association of a mutation in LACC1 with a monogenic form of systemic juvenile idiopathic arthritis
Arthritis and Rheumatology, Volume 67, No. 1, Year 2015
Notification
URL copied to clipboard!
Objective The pathologic basis of systemic juvenile idiopathic arthritis (JIA) is a subject of some controversy, with evidence for both autoimmune and autoinflammatory etiologies. Several monogenic autoinflammatory disorders have been described, but thus far, systemic JIA has only been attributed to a mutation of MEFV in rare cases and has been weakly associated with the HLA class II locus. This study was undertaken to identify the cause of an autosomal-recessive form of systemic JIA.