Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Genomewide analysis of the host response to malaria in Kenyan children
Journal of Infectious Diseases, Volume 191, No. 10, Year 2005
Notification
URL copied to clipboard!
Description
Malaria is a global problem, and there is a critical need for further understanding of the disease process. When malarial parasites invade and develop within the bloodstream, they stimulate a profound host response whose main clinical sign is fever. To explore this response, we measured host gene expression in whole blood from Kenyan children hospitalized with either acute malaria or other febrile illnesses. Genomewide analysis of expression identified 2 principal gene-expression profiles related to neutrophil and erythroid activity. In addition to these general acute responses, a third gene-expression profile was associated with host parasitemia; mediators of erythrophagocytosis and cellular stress were notable components of this response. The delineation of subjects on the basis of patterns of gene expression provides a molecular perspective of the host response to malaria and further functional insight into the underlying processes of pathogenesis. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Griffiths, Michael John
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Kenya, Nairobi
Kenya Medical Research Institute
United States, Stanford
Stanford University School of Medicine
United States, Stanford
Stanford Healthcare
Shafi, Mohammed J.
Kenya, Nairobi
Kenya Medical Research Institute
Popper, Stephen J.
United States, Stanford
Stanford University School of Medicine
Hemingway, Cheryl A.
United Kingdom, London
Imperial College London
Kortok, Moses Mosobo
Kenya, Nairobi
Kenya Medical Research Institute
Wathen, Andrew
United Kingdom, Oxford
University of Oxford
Rockett, Kirk A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Mott, R.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Levin, Michael E.
United Kingdom, London
Imperial College London
Newton, Charles R.J.C.
Kenya, Nairobi
Kenya Medical Research Institute
Marsh, Kevin
Kenya, Nairobi
Kenya Medical Research Institute
Relman, David A.
United States, Stanford
Stanford University School of Medicine
Kwiatkowski, Dominic P.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 124
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1086/429297
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health