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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Elimination and Eradication of Neglected Tropical Diseases with Mass Drug Administrations: A Survey of Experts
PLoS Neglected Tropical Diseases, Volume 7, No. 12, Article e2562, Year 2013
Notification
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Description
Background:Lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths, and trachoma are the five most prevalent neglected tropical diseases in the world, and each is frequently treated with mass drug administrations. We performed a survey of neglected tropical diseases experts to elicit their opinions on the role of mass drug administrations for the elimination of these infections.Methodology/Principal Findings:We sent an online survey to corresponding authors who had published an article about a neglected tropical disease from 2007 to 2011. Of 825 unique authors who were invited to complete the survey, 365 (44.2%) responded, including 234 (28.4%) who answered questions regarding one of the five most prevalent neglected tropical diseases. Respondents had varying opinions about the goals of programmatic activities for their chosen neglected tropical disease, with elimination or eradication identified as the most important goal by 87% of lymphatic filariasis respondents, 66% of onchocerciasis respondents, 55% of trachoma respondents, 24% of schistosomiasis respondents, and 21% of soil-transmitted helminth respondents. Mass drug administrations, other non-medication health measures, and education were generally thought to be more important for elimination than vector control, development of a new tool, or the presence of a secular trend. Drug resistance was thought to be a major limitation of mass drug administrations for all five neglected tropical diseases. Over half of respondents for lymphatic filariasis and trachoma thought that repeated mass drug administrations could eliminate infection within ten years of the initiation of mass treatments.Conclusions/Significance:Respondents for lymphatic filariasis, onchocerciasis, and trachoma were more enthusiastic about the prospects of elimination and eradication than were respondents for schistosomiasis or soil-transmitted helminths. Mass drug administrations were generally believed to be among the most important factors for the success of elimination efforts for each of the five neglected tropical diseases, highlighting the opportunity for integrating drug distributions. © 2013 Keenan et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3855072/bin/pntd.0002562.s001.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3855072/bin/pntd.0002562.s002.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3855072/bin/pntd.0002562.s003.doc
Authors & Co-Authors
Keenan, Jeremy David
United States, San Francisco
University of California, San Francisco
Hotez, Peter J.
United States, Houston
Baylor College of Medicine
United States, Washington
Sabin Vaccine Institute
Amza, Abdou
Niger, Niamey
Universite Abdou Moumouni
Niger
Programme National de Lutte Contre la Cecité
Stoller, Nicole E.
United States, San Francisco
University of California, San Francisco
Gaynor, Bruce D.
United States, San Francisco
University of California, San Francisco
Porco, Travis C.
United States, San Francisco
University of California, San Francisco
Lietman, Thomas M.
United States, San Francisco
University of California, San Francisco
Statistics
Citations: 75
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pntd.0002562
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative