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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A novel WNT10A mutation causes non-syndromic hypodontia in an Egyptian family
Archives of Oral Biology, Volume 59, No. 7, Year 2014
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Description
Objective Tooth agenesis is the most common dental anomaly, whose aetiology still remains to be fully elucidated. The aim of this study was to investigate the genetic cause of non-syndromic hypodontia with clinical variability in an Egyptian family. Design The entire coding regions including exon-intron boundaries of the MSX1, PAX9 and WNT10A genes were investigated by direct sequencing in all affected family members. Results Novel heterozygous mutation inherited in an autosomal dominant manner was identified in the WNT10A gene. This 21-bp deletion combined with 1-bp insertion, c.-14-7delinsC, eliminates the translation initiation codon leading to either no protein production or translation of alternative open reading frames. None of the control subjects (400 chromosomes) were carriers of this novel WNT10A mutation. No pathogenic mutations were found in the MSX1 and PAX9 genes. Conclusions The novel c.-14-7delinsC mutation might be the etiological variant of the WNT10A gene responsible for the permanent tooth agenesis in the Egyptian family. WNT10A is a major candidate gene for non-syndromic hypodontia. © 2014 Elsevier Ltd.
Authors & Co-Authors
Abdalla, E. M.
Egypt, Alexandria
Alexandria University
Mostowska, Adrianna
Poland, Poznan
Poznan University of Medical Sciences
Jagodziński, Paweł P.
Poland, Poznan
Poznan University of Medical Sciences
Dwidar, Karin
Egypt, Alexandria
Faculty of Dentistry
Ismail, Suzan Roushdy
Egypt, Alexandria
Alexandria University
Statistics
Citations: 27
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.archoralbio.2014.04.004
ISSN:
00039969
e-ISSN:
18791506
Research Areas
Cancer
Genetics And Genomics
Health System And Policy