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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High mortality rates for very low birth weight infants in developing countries despite training
Pediatrics, Volume 126, No. 5, Year 2010
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Description
OBJECTIVE: The goal was to determine the effect of training in newborn care and resuscitation on 7-day (early) neonatal mortality rates for very low birth weight (VLBW) infants. The study was designed to test the hypothesis that these training programs would reduce neonatal mortality rates for VLBW infants. METHODS: Local instructors trained birth attendants from 96 rural communities in 6 developing countries in protocol and data collection, the World Health Organization Essential Newborn Care (ENC) course, and a modified version of the American Academy of Pediatrics Neonatal Resuscitation Program (NRP), by using a train-the-trainer model. To test the impact of ENC training, data on infants of 500 to 1499 g were collected by using a before/after, active baseline, controlled study design. A cluster-randomized, controlled trial design was used to test the impact of the NRP. RESULTS: A total of 1096 VLBW (500-1499 g) infants were enrolled, and 98.5% of live-born infants were monitored to 7 days. All-cause, 7-day neonatal mortality, stillbirth, and perinatal mortality rates were not affected by ENC or NRP training. CONCLUSIONS: Neither ENC nor NRP training of birth attendants decreased 7-day neonatal, stillbirth, or perinatal mortality rates for VLBW infants born at home or at first-level facilities. Encouragement of delivery in a facility where a higher level of care is available may be preferable when delivery of a VLBW infant is expected. Copyright © 2010 by the American Academy of Pediatrics.
Authors & Co-Authors
Carlo, Waldemar A.
United States, Birmingham
The University of Alabama at Birmingham
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
Goudar, Shivaprasad S.
India, Belgaum
Jawaharlal Nehru Medical College Belgaum
Jehan, Imtiaz
Pakistan, Karachi
The Aga Khan University
Chomba, Elwyn Nachanya
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
Zambia, Lusaka
University Teaching Hospital Lusaka
Tshefu, Antoinette Kitoto
Democratic Republic Congo, Kinshasa
Kinshasa School of Public Health
Garcés, Ana Lucía
Guatemala, Guatemala City
San Carlos University
Parida, Sailajanandan N.
India, Cuttak
Sriram Chandra Bhanja Medical College
Althabe, Fernando A.
Argentina, Buenos Aires
Institute for Clinical Effectiveness and Health Policy, Ciudad Autonoma de Buenos Aires
McClure, Elizabeth M.
United States, Research Triangle Park
Rti International
Derman, Richard J.
United States, Kansas City
University of Missouri-kansas City
Goldenberg, Robert L.
United States, Philadelphia
Drexel University College of Medicine
Bose, Carl Lewis
United States, Chapel Hill
Unc School of Medicine
Hambidge, K. Michael
United States, Aurora
University of Colorado Anschutz Medical Campus
Panigrahi, Pinaki
United States, Baltimore
University of Maryland School of Medicine
Buekens, Pierre M.
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
Chakraborty, Hrishikesh
United States, Research Triangle Park
Rti International
Hartwell, Tyler D.
United States, Research Triangle Park
Rti International
Moore, Janet L.
United States, Research Triangle Park
Rti International
Wright, Linda L.
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Statistics
Citations: 51
Authors: 19
Affiliations: 17
Identifiers
Doi:
10.1542/peds.2010-1183
ISSN:
00314005
e-ISSN:
10984275
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Randomised Control Trial
Grounded Theory