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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Isolation and characterization of simian immunodeficiency virus from African white-crowned mangabey monkeys (Cercocebus torquatus lunulatus)
Archives of Virology, Volume 129, No. 1-4, Year 1993
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Description
Forty-eight of 236 sera from seven species of African non-human primates in Kenya, including those of white-crowned mangabey monkeys (Cercocebus torquatus lunulatus) had antibodies to simian immunodeficiency viruses (SIVs). Isolates of simian lentivirus were obtained from seropositive white-crowned mangabey monkeys which are indigenous in West Africa. This virus, designated as SIVWCM, appeared morphologically similar to HIV by electron microscopy, showed Mg2+-dependent reverse transcriptase activity, and induced cytopathic effects in human CD 4-positive cells. Western blotting analysis revealed that env products of SIVWCM cross-reacted with those of SIVAGM more strongly than with those of HIV-1 and SIVMAC, and clear hybridization bands were detected with an SIVAGM probe. For comparison of the virus sequence with those of other primate lentiviruses, part of the pol gene and the long terminal repeats (LTRs) were amplified and cloned. Sequencing showed that SIVWCM isolates were closely related to SIVAGM isolates. This study suggested that SIVAGM from the Cercopithecus genus and SIVWCM from the Cercocebus genus may be members of an SIV group that is genetically distinct from the SIV from a sooty mangabey monkey (SIVSMM) of the genus Cercocebus, to which the white-crowned mangabey monkey also belongs. © 1993 Springer-Verlag.
Authors & Co-Authors
Tomonaga, Keizo
Japan, Kyoto
Kyoto University
Katahira, Jun
Japan, Kyoto
Kyoto University
Fukasawa, Masashi
Japan, Kyoto
Kyoto University
Hassan, M. A.
Japan, Kyoto
Kyoto University
Kenya, Nairobi
National Museums of Kenya
Kawamura, Meiko
Japan, Kyoto
Kyoto University
Akari, Hirofumi
Japan, Kyoto
Kyoto University
Miura, Tomoyuki
Japan, Kyoto
Kyoto University
Goto, T.
Japan, Takatsuki
Osaka Medical and Pharmaceutical University
Nakai, Masuyo
Japan, Takatsuki
Osaka Medical and Pharmaceutical University
Suleman, Mbaruk Abdalla
Kenya, Nairobi
National Museums of Kenya
Isahakia, Mohammed A.
Kenya, Nairobi
National Museums of Kenya
Hayami, Masanori
Japan, Kyoto
Kyoto University
Statistics
Citations: 25
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1007/BF01316886
ISSN:
03048608
e-ISSN:
14328798
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries
Kenya