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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A 4,103 marker integrated physical and comparative map of the horse genome
Cytogenetic and Genome Research, Volume 122, No. 1, Year 2008
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Description
A comprehensive second-generation whole genome radiation hybrid (RH II), cytogenetic and comparative map of the horse genome (2n = 64) has been developed using the 5000rad horse × hamster radiation hybrid panel and fluorescence in situ hybridization (FISH). The map contains 4,103 markers (3,816 RH; 1,144 FISH) assigned to all 31 pairs of autosomes and the X chromosome. The RH maps of individual chromosomes are anchored and oriented using 857 cytogenetic markers. The overall resolution of the map is one marker per 775 kilobase pairs (kb), which represents a more than five-fold improvement over the first-generation map. The RH II incorporates 920 markers shared jointly with the two recently reported meiotic maps. Consequently the two maps were aligned with the RH II maps of individual autosomes and the X chromosome. Additionally, a comparative map of the horse genome was generated by connecting 1,904 loci on the horse map with genome sequences available for eight diverse vertebrates to highlight regions of evolutionarily conserved syntenies, linkages, and chromosomal breakpoints. The integrated map thus obtained presents the most comprehensive information on the physical and comparative organization of the equine genome and will assist future assemblies of whole genome BAC fingerprint maps and the genome sequence. It will also serve as a tool to identify genes governing health, disease and performance traits in horses and assist us in understanding the evolution of the equine genome in relation to other species. Copyright © 2008 S. Karger AG.
Authors & Co-Authors
Raudsepp, Terje
Unknown Affiliation
Gustafson-Seabury, A.
Unknown Affiliation
Durkin, Keith
Unknown Affiliation
Wagner, M. L.
Unknown Affiliation
Goh, G.
Unknown Affiliation
Seabury, Christopher M.
Unknown Affiliation
Brinkmeyer-Langford, C.
Unknown Affiliation
Lee, E. J.
Unknown Affiliation
Agarwala, Richa
Unknown Affiliation
Stallknecht-Rice, E.
Unknown Affiliation
Schäffer, Alejandro A.
Unknown Affiliation
Skow, Loren C.
Unknown Affiliation
Tozaki, T.
Unknown Affiliation
Yasue, Hiroshi
Unknown Affiliation
Penedo, Maria Cecília Torres
Unknown Affiliation
Lyons, Leslie A.
Unknown Affiliation
Khazanehdari, Kamal A.
Unknown Affiliation
Binns, Matthew M.
Unknown Affiliation
MacLeod, James N.
Unknown Affiliation
Distl, Ottmar
Unknown Affiliation
Guérin, Gérard
Unknown Affiliation
Leeb, Tosso
Unknown Affiliation
Mickelson, J. R.
Unknown Affiliation
Chowdhary, Bhanu P.
Unknown Affiliation
Statistics
Citations: 53
Authors: 24
Affiliations: 14
Identifiers
Doi:
10.1159/000151313
ISSN:
14248581
Research Areas
Cancer
Genetics And Genomics