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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Blood-derived biomaterials and platelet growth factors in regenerative medicine
Blood Reviews, Volume 27, No. 2, Year 2013
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Description
Several biomaterials can be obtained from human blood. Some are used for clinical indications requiring a high content in fibrinogen, while others are used because they contain multiple platelet growth factors. Mimicking thrombin-induced physiological events of coagulation leading to fibrino-formation and platelet activation, blood biomaterials have critical advantages of being devoid of tissue necrotic effects and of being biodegradable by body enzymes. Fibrin-based biomaterials, known as fibrin glues or fibrin sealants, have been used for more than 30. years as surgical hemostatic and sealing agents, demonstrating benefits in essentially all surgical fields, including reconstructive plastic surgery and wound treatment. Clinical interest in platelet growth factor-rich biomaterials (often known as platelet gels or platelet-rich-plasma) has emerged more recently. Platelet gels are used in clinical situations to achieve wound healing and repair soft and hard tissues. Applications include the healing of recalcitrant ulcers and burns, and stimulation of osseous tissue regeneration in dentistry, implantology, and maxillofacial and plastic surgery. They were evaluated recently in knee osteoarthritis and for the repair of musculoskeletal tissue lesions in sports medicine. Platelet lysates are now used as a substitute for fetal bovine serum and for ex vivo clinical-scale expansion of stem cells, opening new perspectives in regenerative medicine. We present the scientific rationale that prevailed in the development of blood biomaterials, describe their modes of production and biochemical and functional characteristics, and present clinical applications in regenerative medicine. © 2013 Elsevier Ltd.
Authors & Co-Authors
Burnouf, Thierry
Taiwan, Taipei
Taipei Medical University
Goubran, Hadi Alphonse
Canada, Saskatoon
University of Saskatchewan, College of Medicine
Chen, Tim Mo
Taiwan, Taipei
Triservice General Hospital Taiwan
Ou, Kengliang
Taiwan, Taipei
Taipei Medical University
El-Ekiaby, Magdy
Egypt, Giza
Shabrawishi Hospital
Radosevic, Mirjana
France, Lille
Human Protein Process Sciences Hpps
Statistics
Citations: 203
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1016/j.blre.2013.02.001
ISSN:
0268960X
e-ISSN:
15321681
Research Areas
Cancer
Health System And Policy
Violence And Injury