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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Glomerular expression and elevated serum Bcl-2 and Fas proteins in lupus nephritis: Preliminary findings
Clinical and Experimental Immunology, Volume 146, No. 2, Year 2006
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Description
Programmed cell death (apoptosis) is involved in glomerular injuries leading to glomerulonephritis. Bcl-2 and Fas are proteins that promote cell survival and death, respectively. This study tests the hypothesis that lupus nephritis is associated with alterations of Bcl-2 and Fas protein expression. Thirty-six patients with lupus nephritis and 10 controls (normal individuals) were included in this study. Bcl-2 and Fas positive cells were examined in kidney biopsies by immunohistochemistry. Bcl-2 and Fas serum levels were evaluated by enzyme-linked immunosorbent assay (ELISA). In the glomeruli of normal kidneys, Bcl-2 and Fas proteins were completely absent. In lupus nephritis patients, glomerular expression of Bcl-2 and Fas was seen in mesangial cells (1.3 ± 0.1 and 2.0 ± 0.1 for Bcl-2 and Fas, respectively). Similarly, a statistically significantly higher Bcl-2 (217.1 ± 85.9) and Fas (767.9 ± 271) serum levels were found in lupus patients compared to controls (148.6 ± 87, 550.3 ± 91 for Bcl-2 and Fas, P < 0.05). A direct correlation between serum Bcl-2 and Fas and chronicity index was also found. Compared to normal controls, lupus nephritis is associated with glomerular expression and elevated serum levels of Bcl-2 and Fas proteins. These findings suggest possible roles for Bcl-2 and Fas in glomerular injury during evolution of lupus nephritis. The diagnostic, prognostic and therapeutic ramifications of our findings are open to further investigation. © 2006 The Author(s).
Authors & Co-Authors
Fathi, Nihal Ahmad
Egypt, Asyut
Faculty of Medicine
Hussein, Mahmoud Rezk Abdelwahed
Egypt, Asyut
Faculty of Veterinary Medicine
Hassan, Howayda Ismail
Egypt, Asyut
Faculty of Veterinary Medicine
Mosad, Eman
Egypt, Asyut
Faculty of Medicine
Galal, Hanan
Egypt, Asyut
Faculty of Medicine
Afifi, Noha Abdel Halim
Egypt, Asyut
Faculty of Medicine
Statistics
Citations: 34
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1111/j.1365-2249.2006.03219.x
ISSN:
00099104
e-ISSN:
13652249
Research Areas
Cancer
Violence And Injury