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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antiretroviral therapy abrogates association between arginase activity and HIV disease severity
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, No. 11, Year 2010
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Description
Arginase-induced L-arginine deprivation is emerging as a key mechanism for the downregulation of immune responses. We hypothesised that arginase activity increases with disease severity in HIV-seropositive patients. Our results show that peripheral blood mononuclear cells (PBMCs) from 23 HIV-seropositive patients with low CD4+ T cell counts (≤350 cells/μl) expressed significantly more arginase compared with 21 patients with high CD4+ T cell counts. Furthermore, we found a significant association between the two principal prognostic markers used to monitor HIV disease (CD4+ T cell count and plasma viral load) and PBMC arginase activity in antiretroviral therapy naïve patients but not in patients undergoing therapy. © 2010.
Authors & Co-Authors
Cloke, T. E.
United Kingdom, London
Imperial College London
Abebe, Tamrat Asfaw
Ethiopia, Addis Ababa
Addis Ababa University
Hailu, Asrat
Ethiopia, Addis Ababa
Addis Ababa University
Munder, Markus
Germany, Mainz
Johannes Gutenberg-universität Mainz
Taylor, Graham P.
United Kingdom, London
Imperial College London
Müller, Ingrid
United Kingdom, London
Imperial College London
Kropf, Pascale
United Kingdom, London
Imperial College London
Statistics
Citations: 7
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.trstmh.2010.08.004
ISSN:
00359203
Research Areas
Infectious Diseases