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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis of some cyclic methylene 1,3-diaza barbiturates derivatives
Letters in Organic Chemistry, Volume 8, No. 8, Year 2011
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Description
The reaction of 1,3-dimethyl-5-bis(thioethyl)methylene barbituric acid (2) with various vic-diamines leads to the formation of the respective 1,3-diazamethylene barbiturate derivatives 3 (a-f) in high yields. Solid-state 13C-NMR, MS and IR spectral data were employed for the characterization of these compounds. Antimicrobial screening revealed that none of the newly synthesized compounds showed appreciable antibacterial activity. © 2011 Bentham Science Publishers.
Authors & Co-Authors
Sweidan, Kamal
Jordan, Amman
The University of Jordan
Engelmann, Jörn
Germany, Tubingen
Max Planck Institute for Biological Cybernetics
Joshi, Rajendra
Germany, Tubingen
Max Planck Institute for Biological Cybernetics
Mubarak, Mohammad S.
Jordan, Amman
The University of Jordan
El-Abadelah, Mustafa M.
Jordan, Amman
The University of Jordan
Statistics
Citations: 5
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.2174/157017811797249353
ISSN:
15701786