Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Serologic status and measles attack rates among vaccinated and unvaccinated children in rural senegal
Pediatric Infectious Disease Journal, Volume 14, No. 3, Year 1995
Notification
URL copied to clipboard!
Description
During a measles vaccine trial in a rural area of Senegal, antibody status was examined within 10 days of exposure for 228 previously vaccinated and 313 unvaccinated children more than 12 months old who were exposed to measles at home. Thirty–six percent of the children developed clinical measles, the clinical diagnosis being confirmed for 135 of the 137 children from whom 2 blood samples were collected. Vaccine efficacy was 90% (95% confidence interval, 83 to 94%). The hemagglutinin-inhibiting antibodies (HI) or plaque neutralizing antibodies (PN) assays were equally efficient in predicting susceptibility and protection against measles. Vaccinated children who had no detectable HI or PN antibodies at exposure had significant protection against measles compared with seronegative unvaccinated children (HI vaccine efficacy, 49% (95% confidence interval, 21 to 68%); PN vaccine efficacy, 43% (95% confidence interval, 12 to 62%). The attack rate was high for children with a titer of 40 to 125 mIU) 67% (4 of 6) of those with a positive hemagglutinin–inhibiting antibody test and 36% (13 of 36) of those with a positive PN test developed measles. Attack rates among children with HI or PN titers above 125 mIU were 2% (6 of 295) and 3% (7 of 258), respectively. Because titers of ≤120 mIU have been found to offer little protection in another study, this antibody level may be the best screening value for assessing susceptibility and protection against measles. However, it should be noted that many seronegative vaccinated children are protected against measles infection. © 1995 by Williams … Wilkins.
Authors & Co-Authors
Samb, Badara
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Aaby, Peter
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Denmark, Copenhagen
Dansk Institut for Klinisk Epidemiologi
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Coll-Seck, Anna Marie
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Rahman, Seedy
Gambia, Banjul
Medical Research Council Laboratories Gambia
Bennett, John V.
United States, Atlanta
Task Force for Child Survival and Development
Markowitz, Lauri Ellen
United States, Atlanta
Centers for Disease Control and Prevention
Simondon, François
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Statistics
Citations: 139
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1097/00006454-199503000-00007
ISSN:
08913668
e-ISSN:
15320987
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Senegal