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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Patterns of genomic differentiation between ecologically differentiated M and S forms of anopheles gambiae in West and Central Africa
Genome Biology and Evolution, Volume 4, No. 12, Year 2012
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Description
Anopheles gambiae M and S are thought to be undergoing ecological speciation by adapting to different larval habitats. Toward an improved understanding of the genetic determinants and evolutionary processes shaping their divergence, we used a 400,000 single-nucleotide polymorphism(SNP) genotyping array to characterize patterns of genomic differentiation between four geographically paired M and S population samples from West and Central Africa. In keeping with recent studies based on more limited genomic or geographic sampling, divergence was not confined to a few isolated "speciation islands." Divergence was both widespread across the genome and heterogeneous. Moreover, we find consistent patterns of genomic divergence across sampling sites and mutually exclusive clustering of M and S populations using genetic distances based on all 400,000 SNPs, implying that M and S are evolving collectively across the study area. Nevertheless, the clustering of local M and Spopulations using genetic distances based on SNPs from genomic regions of low differentiation is consistent with recent gene flow and introgression. To account for these data and reconcile apparent paradoxes in reported patterns of M-S genomic divergence and hybridization, we propose that extrinsic ecologically based postmating barriers vary in strength as environmental conditions fluctuate or change. © 2012 The Author(s).
Authors & Co-Authors
Reidenbach, Kyanne R.
United States, Notre Dame
University of Notre Dame
Neafsey, Daniel E.
United States, Cambridge
Broad Institute
Costantini, Carlo
France, Montpellier
Ird Centre de Montpellier
Cameroon, Yaounde
Organisation de Coordination Pour la Lutte Contre Les Endémies en Afrique Centrale Cameroon
Sagnon, N'Falé F.
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Simard, Frédéric R.
France, Montpellier
Ird Centre de Montpellier
Ragland, Gregory J.
United States, Notre Dame
University of Notre Dame
Egan, Scott P.
United States, Notre Dame
University of Notre Dame
Feder, Jeffrey L.
United States, Notre Dame
University of Notre Dame
Muskavitch, Marc A.T.
United States, Cambridge
Broad Institute
United States, Chestnut Hill
Boston College
United States, Boston
Harvard T.h. Chan School of Public Health
Besansky, Nora J.
United States, Notre Dame
University of Notre Dame
Statistics
Citations: 66
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1093/gbe/evs095
e-ISSN:
17596653
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study