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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Enhanced tuberculosis identification through 1-month follow-up of smear-negative tuberculosis suspects
International Journal of Tuberculosis and Lung Disease, Volume 15, No. 4, Year 2011
Notification
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Description
SETTING: Bandim Health Project, Bissau, Guinea-Bissau. OBJECTIVE: To conduct tuberculosis (TB) screening among former TB suspects in whom TB had been ruled out on initial consultation and therefore assumed to be TB-negative (aTBneg). DESIGN: In a cohort follow-up study, 'aTBneg suspects' were screened for symptoms from 1 month after the initial negative sputum smear examination. Symptomatic individuals were referred for clinical re-examination and human immunodeficiency virus (HIV) testing. RESULTS: Among 428 TB suspects presenting over a 10-month period in 2007, 80% (343) were smear-negative. Of these, 21 were subsequently diagnosed with smear-negative TB. Of the remaining 322 aTBneg patients, 212 were followed up and symptoms were examined ≥1 month after initial examination. Among followed up patients, 89 (42%) were still symptomatic: five were diagnosed with TB on the basis of repeated sputum smears and chest X-ray. Of 44 symptomatic patients, 39% (n = 17) were HIV-infected. Thirteen (4%) of the 322 aTBneg suspects died before follow-up. CONCLUSION: A large proportion of aTBneg patients remained symptomatic after 1 month. Several TB cases had initially not been diagnosed, and HIV infection was highly prevalent. aTBneg suspects have a high mortality rate and need increased attention from both TB and HIV programmes. © 2011 The Union.
Authors & Co-Authors
Porskrog, A.
Ghana, Accra
Indepth Network
Denmark, Aarhus
Aarhus Universitetshospital
Bjerregaard-Andersen, Morten
Ghana, Accra
Indepth Network
Denmark, Aarhus
Aarhus Universitetshospital
Oliveira-Souto, Inés
Ghana, Accra
Indepth Network
Joaquím, Luis Carlos
Ghana, Accra
Indepth Network
Camara, C.
Ghana, Accra
Indepth Network
Andersen, Paul Lehm
Denmark, Aarhus
Aarhus Universitetshospital
Rabna, Paulo
Ghana, Accra
Indepth Network
Aaby, Peter
Ghana, Accra
Indepth Network
Denmark, Copenhagen
Statens Serum Institut
Wejse, Christian
Ghana, Accra
Indepth Network
Denmark, Aarhus
Aarhus Universitetshospital
Statistics
Citations: 25
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.5588/ijtld.10.0353
ISSN:
10273719
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Locations
Guinea
Guinea-Bissau