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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Vulpeculin: A novel and abundant lipocalin in the urine of the common brushtail possum, Trichosurus vulpecula: Brushtail possum urinary lipocalin
Open Biology, Volume 10, No. 10, Article 200218, Year 2020
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Description
Lipocalins are a family of secreted proteins. They are capable of binding small lipophilic compounds and have been extensively studied for their role in chemosignalling in rodent urine. Urine of the common brushtail possum (Trichosurus vulpecula) contains a prominent glycoprotein of 20 kDa, expressed in both sexes. We have isolated this protein and determined its primary sequence by mass spectrometry, including the use of metabolic labelling to resolve the leucine/isoleucine isobaric ambiguity. The protein sequence was identified as a lipocalin, and phylogenetic analysis grouped the protein with other marsupial lipocalin sequences in a phylogenetic clade distinct from established cross-species lipocalin sub-families. The pattern of expression in possum urine and the similarity in sequence and structure to other lipocalins suggests this protein may have a role in brushtail possum chemosignalling. © 2020 The Authors.
Authors & Co-Authors
Antonopoulos, Aristotelis
United Kingdom, London
Imperial College London
Dell, Anne
United Kingdom, London
Imperial College London
Haslam, Stuart M.
United Kingdom, London
Imperial College London
Linklater, W. L.
United States, Sacramento
California State University, Sacramento
Hurst, Jane L.
United Kingdom, Liverpool
University of Liverpool
Beynon, Robert Jeffrey
United Kingdom, Liverpool
University of Liverpool
Statistics
Citations: 3
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1098/rsob.200218
ISSN:
20462441
Research Areas
Noncommunicable Diseases