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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells
AIDS, Volume 24, No. 4, Year 2010
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Description
Objective: CD4 T-cell depletion is central to HIV pathogenesis. However, the relative impact of HIV on Th17 and regulatory T cell (Treg) subsets remains unclear. CD161 CD4 cells are a recently identified, gut-homing Th17 precursor population. The balance between pro-inflammatory Th17 and immunoregulatory Tregs may be critical in HIV pathogenesis. This study addressed changes in CD161, Th17 and Treg subsets during untreated HIV infection. Methods: Peripheral blood mononuclear cells were isolated from HIV-infected and HIV-uninfected individuals and stained to characterize CD161 CD4 cells, Th17 cells [by elaboration of interleukin (IL)-17A], Tregs (CD3CD4CD25FoxP3 cells) and CD8 activation (CD38/HLA-DR cells). In-vitro infectability of CD161 and Th17 cells by HIV was assessed in healthy donor CD4 cells by intracellular p24 expression. Results: Peripheral blood Th17 cells were depleted 10-fold in HIV-infected, compared to HIV-uninfected individuals (P < 0.0001) across a range of disease stages, accompanied by a significant reduction of CD161 T cells (P = 0.024). Both Th17 cells and CD161 CD4 T cells were permissive to HIV replication in vitro. Profound loss of Th17 cells before the onset of advanced disease contrasted with a gradual decline in absolute Tregs during HIV disease progression in untreated individuals followed longitudinally (R = 0.71, P = 0.003). Loss of Tregs was associated with increased immune activation (R =-0.33, P = 0.03). Conclusion: HIV-infected individuals showed profound loss of Th17 cells, which may impair mucosal immunity, and reduced CD161 CD4 cells, which may limit Th17 reconstitution. A gradual decline in Tregs during disease progression was associated with increased immune activation. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Prendergast, Andrew J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
John Radcliffe Hospital
Prado, Julia Garcia
United Kingdom, Oxford
University of Oxford
Kang, Yuhoi
United Kingdom, Oxford
University of Oxford
Chen, Fabian
United Kingdom, Reading
Royal Berkshire Nhs Foundation Trust
Riddell, Lynn A.
United Kingdom, Northampton
Northampton General Hospital
Luzzi, Graz A.
United Kingdom, High Wycombe
Wycombe Hospital
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
University of Oxford
Klenerman, Paul
United Kingdom, Oxford
John Radcliffe Hospital
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 134
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1097/QAD.0b013e3283344895
ISSN:
14735571
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study