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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
C-reactive protein levels increase during HIV-1 disease progression in rakai, Uganda, despite the absence of microbial translocation
Journal of Acquired Immune Deficiency Syndromes, Volume 54, No. 5, Year 2010
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Description
Introduction: Microbial translocation has been implicated as a contributing factor to the heightened immune activation observed during HIV-1 disease progression. When examined in a longitudinal study of HIV-1 seroconverters in Rakai, Uganda, microbial translocation was not associated with HIV-1 disease progression. However, the role of general immune activation in HIV disease progression in this population was not fully examined. Methods: Longitudinal serum samples of HIV-1 seroconverters in three HIV-1 disease progression groups [long-term nonprogressors (LTNP), standard progressors (SP), and rapid progressors (RP)] from Rakai, Uganda, were tested for levels of C-reactive protein (CRP), a marker for immune activation. Results: CRP levels significantly increased in the SP group (P < 0.0001) but not in the RP group or the LTNP group. CRP levels during the first year post-HIV seroconversion in the RP group were significantly higher than those observed in the LTNP group (P < 0.05). For the entire population, CRP levels negatively correlated with lipopolysaccharide levels (P < 0.05) and were not associated with endotoxin antibody levels. Conclusions: This study suggests that in this population, increased immune activation is significantly associated with HIV-1 disease progression but not microbial translocation. © 2010 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Redd, Andrew D.
United States, Bethesda
National Institutes of Health Nih
Eaton, Kevin P.
United States, Baltimore
Johns Hopkins School of Medicine
Kong, Xiangrong
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Laeyendecker, Oliver B.
United States, Bethesda
National Institutes of Health Nih
Lutalo, Tom
Uganda, Kalisizo
Rakai Health Sciences Program
Wawer, Maria J.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Gray, Ronald H.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Serwadda, David Musoke
Uganda, Kalisizo
Rakai Health Sciences Program
Uganda, Kampala
Makerere University
Quinn, Thomas Charles
United States, Bethesda
National Institutes of Health Nih
United States, Baltimore
Johns Hopkins School of Medicine
Statistics
Citations: 47
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1097/QAI.0b013e3181e0cdea
ISSN:
15254135
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Uganda