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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
RHD allele distribution in Africans of Mali
BMC Genetics, Volume 4, Article 14, Year 2003
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Description
Background: Aberrant and non-functional RHD alleles are much more frequent in Africans than in Europeans. The DAU cluster of RHD alleles exemplifies that the alleles frequent in Africans have evaded recognition until recently. A comprehensive survey of RHD alleles in any African population was lacking. Results: We surveyed the molecular structure and frequency of RHD alleles in Mali (West Africa) by evaluating 116 haplotypes. Only 69% could be attributed to standard RHD (55%) or the RHD deletion (14%). The aberrant RHD allele DAU-0 was predicted for 19%, RHD ψ for 7% and Ccdes for 4% of all haplotypes. DAU-3 and the new RHD allele RHD(L207F), dubbed DMA, were found in one haplotype each. A PCR-RFLP for the detection of the hybrid Rhesus box diagnostic for the RHD deletion in Europeans was false positive in 9 individuals, including all carriers of RHDψ . Including two silent mutations and the RHD deletion, a total of 9 alleles could be differentiated. Conclusion: Besides standard RHD and the RHD deletion, DAU-0, RHDψ and Ccdes are major alleles in Mali. Our survey proved that the most frequent alleles of West Africans have been recognized allowing to devise reliable genotyping and phenotyping strategies. ©2004 Wagner et al; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC222912/bin/1471-2156-4-14-S1.rtf
Authors & Co-Authors
Wagner, Franz Friedrich
Germany, Ulm
Institut Für Klinische Transfusionsmedizin Und Immungenetik Ulm
Germany, Ulm
Inst. Clin. Trans. Med./immunogenet.
Germany, Berlin
Deutsches Rotes Kreuz
Moulds, Joann M.
United States, Philadelphia
Drexel University College of Medicine
Tounkara, Anatole
Mali, Bamako
Centre National de Transfusion Sanguine
Kouriba, Bourèma
Mali, Bamako
Centre National de Transfusion Sanguine
Flegel, W. A.
Germany, Ulm
Institut Für Klinische Transfusionsmedizin Und Immungenetik Ulm
Germany, Ulm
Inst. Clin. Trans. Med./immunogenet.
Statistics
Citations: 66
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1186/1471-2156-4-14
ISSN:
14712156
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Multi-countries
Mali