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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Digital phenotyping: An equal opportunity approach to reducing disparities in Alzheimer's disease and related dementia research
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Volume 15, No. 4, Article e12495, Year 2023
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Description
A rapidly aging world population is fueling a concomitant increase in Alzheimer's disease (AD) and related dementias (ADRD). Scientific inquiry, however, has largely focused on White populations in Australia, the European Union, and North America. As such, there is an incomplete understanding of AD in other populations. In this perspective, we describe research efforts and challenges of cohort studies from three regions of the world: Central America, East Africa, and East Asia. These cohorts are engaging with the Davos Alzheimer's Collaborative (DAC), a global partnership that brings together cohorts from around the world to advance understanding of AD. Each cohort is poised to leverage the widespread use of mobile devices to integrate digital phenotyping into current methodologies and mitigate the lack of representativeness in AD research of racial and ethnic minorities across the globe. In addition to methods that these three cohorts are already using, DAC has developed a digital phenotyping protocol that can collect ADRD-related data remotely via smartphone and/or in clinic via a tablet to generate a common data elements digital dataset that can be harmonized with additional clinical and molecular data being collected at each cohort site and when combined across cohorts and made accessible can provide a global data resource that is more racially/ethnically represented of the world population. © 2023 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Authors & Co-Authors
Britton, Gabrielle B.
Panama, Panama City
Instituto de Investigaciones Cientificas y Servicios de Alta Tecnologia, Indicasat-aip
Panama, Panama City
Universidad Católica Santa María la Antigua
Levey, Aĺlan I.
United States, Atlanta
Emory University School of Medicine
Philippakis, Anthony A.
United States, Cambridge
Harvard University
Mushi, Declare L.
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Paddick, Stella Maria
United Kingdom, Tyne and Wear
Gateshead Health Nhs Foundation Trust
Statistics
Authors: 5
Affiliations: 11
Identifiers
Doi:
10.1002/dad2.12495
ISSN:
23528729
Research Areas
Health System And Policy
Mental Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Multi-countries