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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Quantitative determinations of levofloxacin and rifampicin in pharmaceutical and urine samples using nuclear magnetic resonance spectroscopy
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Volume 62, No. 1-3, Year 2005
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Description
Rapid, specific and simple methods for determining levofloxacin and rifampicin antibiotic drugs in pharmaceutical and human urine samples were developed. The methods are based on 1H NMR spectroscopy using maleic acid as an internal standard and DMSO-d6 as NMR solvent. Integration of NMR signals at 8.9 and 8.2 ppm were, respectively, used for calculating the concentration of levofloxacin and rifampicin drugs per unit dose. Maleic acid signal at 6.2 ppm was used as the reference signal. Recoveries of (97.0-99.4) ± 0.5 and (98.3-99.7) ± 1.08% were obtained for pure levofloxacin and rifampicin, respectively. Corresponding recoveries of 98.5-100.3 and 96.8-100.0 were, respectively, obtained in pharmaceutical capsules and urine samples. Relative standard deviations (R.S.D.) values ≤2.7 were obtained for analyzed drugs in pure, pharmaceutical and urine samples. Statistical Student's t-test gave t-values ≤2.87 indicating insignificant difference between the real and the experimental values at the 95% confidence level. F-test revealed insignificant difference in precisions between the developed NMR methods and each of fluorimetric and HPLC methods for analyzing levofloxacin and rifampicin. © 2005 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Salem, Alaa A.
United Arab Emirates, Al Ain
United Arab Emirates University
Egypt, Giza
Faculty of Science
Mossa, Hussein A.
Egypt, Giza
Cairo University
Barsoum, Barsoum N.
Egypt, Giza
Cairo University
Statistics
Citations: 49
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1016/j.saa.2005.01.016
ISSN:
13861425
Research Areas
Cancer
Study Approach
Quantitative