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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
SNP/RD typing of Mycobacterium tuberculosis beijing strains reveals local and worldwide disseminated clonal complexes
PLoS ONE, Volume 6, No. 12, Article e28365, Year 2011
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Description
The Beijing strain is one of the most successful genotypes of Mycobacterium tuberculosis worldwide and appears to be highly homogenous according to existing genotyping methods. To type Beijing strains reliably we developed a robust typing scheme using single nucleotide polymorphisms (SNPs) and regions of difference (RDs) derived from whole-genome sequencing data of eight Beijing strains. SNP/RD typing of 259 M. tuberculosis isolates originating from 45 countries worldwide discriminated 27 clonal complexes within the Beijing genotype family. A total of 16 Beijing clonal complexes contained more than one isolate of known origin, of which two clonal complexes were strongly associated with South African origin. The remaining 14 clonal complexes encompassed isolates from different countries. Even highly resolved clonal complexes comprised isolates from distinct geographical sites. Our results suggest that Beijing strains spread globally on multiple occasions and that the tuberculosis epidemic caused by the Beijing genotype is at least partially driven by modern migration patterns. The SNPs and RDs presented in this study will facilitate future molecular epidemiological and phylogenetic studies on Beijing strains. © 2011 Schüerch et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s001.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s002.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s003.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s004.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s005.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s006.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s007.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s008.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s009.txt
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s010.txt
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s011.txt
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s012.txt
https://efashare.b-cdn.net/share/pmc/articles/PMC3230589/bin/pone.0028365.s013.txt
Authors & Co-Authors
Schürch, Anita Christina
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Netherlands, Nijmegen
Radboud University Medical Center
Kremer, Kristin
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Hendriks, Amber C.A.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Freyee, Benthe
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
McEvoy, Christopher R.E.
South Africa, Stellenbosch
Stellenbosch University
Australia, Melbourne
University of Melbourne
van Crevel, Reinout
Netherlands, Nijmegen
Radboud University Medical Center
Boeree, Martin Johan
Netherlands, Nijmegen
Radboud University Medical Center
Van Helden, Paul D.
South Africa, Stellenbosch
Stellenbosch University
Warren, Robin Mark
South Africa, Stellenbosch
Stellenbosch University
Siezen, Roland J.
Netherlands, Nijmegen
Radboud University Medical Center
van Soolingen, Dick
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Netherlands, Nijmegen
Radboud University Medical Center
Statistics
Citations: 36
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0028365
e-ISSN:
19326203
Research Areas
Genetics And Genomics