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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
A novel TaqI polymorphism in the coding region of the ovine TNXB gene in the MHC class III region: Morphostructural and physiological influences
Biochemical Genetics, Volume 52, No. 1-2, Year 2014
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Description
The tenascin-XB (TNXB) gene has antiadhesive effects, functions in matrix maturation in connective tissues, and localizes to the major histocompatibility complex class III region. We hypothesized that it may influence adaptive physiological response through an effect on blood vessel function. We identified a novel g.1324 A→G polymorphism at a TaqI recognition site in a 454 bp fragment of ovine TNXB and genotyped it in 150 Nigerian sheep using PCR-RFLP. The missense mutation changes glutamic acid (GAA) to glycine (GGA). Among SNP genotypes, significant differences (P < 0.05) were observed in body weight and fore cannon bone length. Interaction effects of breed, SNP genotype, and geographic location had a significant effect (P < 0.05) on chest girth. The SNP genotype was significantly (P < 0.05) associated with physiological traits of pulse rate and skin temperature. The observed effect of this novel polymorphism may be mediated through its role in connective tissue biology, requiring further association and functional studies. © 2013 Springer Science+Business Media New York.
Authors & Co-Authors
Ajayi, Oyeyemi Olugbenga
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
United States, Ithaca
Cornell University
Adefenwa, Mufliat A.
Nigeria, Lagos
University of Lagos
United States, Ithaca
Cornell University
Agaviezor, Brilliant Ogagaoghene
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Nigeria, Port Harcourt
University of Port Harcourt
United States, Ithaca
Cornell University
Ikeobi, Christian Obiora Ndubuisi
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Wheto, Mathew Y.
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Okpeku, M.
Nigeria, Amassoma
Niger Delta University
Amusan, Samuel A.
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Yakubu, Abdulmojeed
Nigeria, Keffi
Nasarawa State University
United States, Ithaca
Cornell University
De Donato-Capote, Marcos
Venezuela, Cumana
Universidad de Oriente - Venezuela
United States, Ithaca
Cornell University
Peters, Sunday Olusola
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
United States, Mount Berry
Berry College
United States, Ithaca
Cornell University
Imumorin, Ikhide G.
United States, Ithaca
Cornell University
Statistics
Citations: 11
Authors: 11
Affiliations: 8
Identifiers
Doi:
10.1007/s10528-013-9622-9
ISSN:
00062928
e-ISSN:
15734927
Research Areas
Cancer
Genetics And Genomics