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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Mutagen sensitivity has high heritability: Evidence from a twin study
Cancer Research, Volume 66, No. 12, Year 2006
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Description
Despite numerous studies showing that mutagen sensitivity is a cancer predisposition factor, the heritability of mutagen sensitivity has not been clearly established. In this report, we used a classic twin study design to examine the role of genetic and environmental factors on the mutagen sensitivity phenotype. Mutagen sensitivity was measured in peripheral blood lymphocytes from 460 individuals [148 pairs of monozygotic (MZ) twins, 57 pairs of dizygotic (DZ) twins, and 50 siblings]. The intraclass correlation coefficients were all significantly higher in MZ twins than in dizygotes (DZ pairs and MZ-sibling pairs combined) for sensitivity to four different mutagen challenges. Applying biometric genetic modeling, we calculated a genetic heritability of 40.7%, 48.0%, 62.5%, and 58.8% for bleomycin, benzo[a]pyrene diol epoxide, γ-radiation, and 4-nitroquinoline-1-oxide sensitivity, respectively. This study provides the strongest and most direct evidence that mutagen sensitivity is highly heritable, thereby validating the use of mutagen sensitivity as a cancer susceptibility factor. ©2006 American Association for Cancer Research.
Authors & Co-Authors
Wu, Xifeng
United States, Houston
The University of Texas Md Anderson Cancer Center
Amos, Christopher I.
United States, Houston
The University of Texas Md Anderson Cancer Center
de Andrade, Mariza A.
United States, Rochester
Mayo Clinic
Benowitz, Neal L.
United States, San Francisco
University of California, San Francisco
Shields, Peter G.
United States, Washington, D.c.
Georgetown Lombardi Comprehensive Cancer Center
Swan, Gerald E.
United States, Menlo Park
Sri International
Statistics
Citations: 71
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1158/0008-5472.CAN-06-1007
ISSN:
00085472
Research Areas
Cancer
Genetics And Genomics