Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Determinants of estimated insulin resistance and β-cell function in Indian, Creole and Chinese Mauritians
Diabetes Research and Clinical Practice, Volume 10, No. 3, Year 1990
Notification
URL copied to clipboard!
Description
Associations with insulin resistance and islet β-cell function have been studied cross-sectionally in a population-based sample of 4278 Mauritians comprising Asian Indian, Creole and Chinese subjects. Insulin resistance and β-cell function were estimated by a computer solved model based on fasting plasma glucose and insulin concentrations. Insulin resistance increased with declining glucose tolerance, whereas β-cell function was highest in subjects with impaired glucose tolerance (IGT) and lowest in those with non-insulin-dependent diabetes mellitus (NIDDM). Indian subjects had the highest β-cell function, while ethnic differences in insulin sensitivity were-less marked. This may indicate that deranged β-cell function rather than insulin resistance is the primary determinant of hyperinsulinaemia and glucose intolerance in Asian Indians. β-Cell function declined with age more sharply than did insulin sensitivity, suggesting that the age-related decline in glucose tolerance is primarily related to loss of β-cell function. Body mass index, waist/hip ratio, physical inactivity and female sex were independently associated with insulin resistance and β-cell function. Subjects with a family history of diabetes had increased insulin resistance, irrespective of glucose tolerance. This or similar models may have application in longitudinal population-based studies which seek to determine the relative contributions of insulin resistance and β-cell function to the aetio-pathogenesis of NIDDM. © 1990.
Authors & Co-Authors
Dowse, Gary K.
Australia, Melbourne
Baker Heart and Diabetes Institute
Qin, H.
China, Shanghai
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Collins, Veronica Rose
Australia, Melbourne
Baker Heart and Diabetes Institute
Zimmet, Paul Z.
Australia, Melbourne
Baker Heart and Diabetes Institute
Alberti, Kurt George M.M.A.
United Kingdom, Newcastle
Newcastle University
Gareeboo, Hassam
Mauritius, Port Louis
Ministry of Health
Statistics
Citations: 30
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/0168-8227(90)90070-A
ISSN:
01688227
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female