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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome and transcriptome of the porcine whipworm Trichuris suis
Nature Genetics, Volume 46, No. 7, Year 2014
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Description
Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at ∼140-fold coverage of adult male and female T. suis and ∼80-Mb draft assemblies. We explore stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs.© 2014 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Jex, Aaron R.
Australia, Melbourne
University of Melbourne
Nejsum, Peter
Denmark, Copenhagen
Københavns Universitet
Schwarz, Erich M.
Australia, Melbourne
University of Melbourne
United States, Ithaca
Cornell University
Hu, Li
China, Shenzhen
Bgi-shenzhen
Young, Neil D.
Australia, Melbourne
University of Melbourne
Hall, Ross S.
Australia, Melbourne
University of Melbourne
Korhonen, Pasi K.
Australia, Melbourne
University of Melbourne
Liao, Shengguang
China, Shenzhen
Bgi-shenzhen
Thamsborg, Stig Milan
Denmark, Copenhagen
Københavns Universitet
Xia, Jinquan
China, Shenzhen
Bgi-shenzhen
Xu, Pengwei
China, Shenzhen
Bgi-shenzhen
Wang, Shaowei
China, Shenzhen
Bgi-shenzhen
Scheerlinck, Jean Pierre Yves Ves
Australia, Melbourne
University of Melbourne
Hofmann, Andreas
Australia, Brisbane
Griffith University
Sternberg, Paul W.
United States, Pasadena
California Institute of Technology
Wang, Jun
China, Shenzhen
Bgi-shenzhen
Denmark, Copenhagen
Københavns Universitet
Saudi Arabia, Jeddah
King Abdulaziz University
Macao, Taipa
Macau University of Science and Technology
Hong Kong, Hong Kong
The University of Hong Kong
Gasser, Robin B.
Australia, Melbourne
University of Melbourne
Statistics
Citations: 93
Authors: 17
Affiliations: 9
Identifiers
Doi:
10.1038/ng.3012
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Food Security
Health System And Policy
Maternal And Child Health
Participants Gender
Male
Female