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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antibodies to a synthetic peptide from the preS 120–145 region of the hepatitis B virus envelope are virus-neutralizing
Topics in Catalysis, Volume 4, No. 1, Year 1986
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Description
Studies with synthetic peptides have provided evidence for the presence of preS coded sequences in the envelope (env) proteins of hepatitis B virus (HBV) and indicated that these sequences are involved in the specific attachment of HBV to liver cells. Scanning of the preS sequence for immunodominant continuous epitopes identifies the sequence within residues preS (120–145) as the most immunogenic in eliciting antibodies recognizing HBV and as the most efficiently binding antibodies from sera of rabbits and humans immunized with HBV env proteins. To assess the potential of preS (120–145) as a synthetic vaccine against hepatitis B, in vitro neutralization of the virus by rabbit antiserum to the peptide was assayed hi chimpanzees. The anhnals, subsequently proven to be susceptible to HBV infection, did not develop hepatitis B as judged by negative serological tests for HBV-associated antigens and antibodies and by normal serum alanine aminotransferase levels and normal liver biopsies. These results establish the role of preS domains in the process of virus neutralization and the potential of synthetic preS analogues for hepatitis B vaccination. © 1986, Butterworth & Co. (Publishers) Ltd.. All rights reserved.
Authors & Co-Authors
Neurath, A. Robert
United States, New York
New York Blood Center
Kent, Stephen B.H.
United States, Pasadena
California Institute of Technology
Parker, Karen
United States, Pasadena
California Institute of Technology
Prince, Alfred M.
United States, New York
New York Blood Center
United States, Pasadena
California Institute of Technology
Strick, Nathan
United States, New York
New York Blood Center
Brotman, Betsy H.
United States, New York
New York Blood Center
Liberia, Monrovia
Liberian Institute for Biomedical Research
Sproul, Phyllis
United States, New York
New York Blood Center
Statistics
Citations: 197
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/S0264-410X(86)80001-9
ISSN:
0264410X
Research Areas
Infectious Diseases