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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
An aqueous extract of Limoniastrum guyonianum gall induces anti-tumor effects in melanoma-injected mice via modulation of the immune response
Food and Chemical Toxicology, Volume 69, Year 2014
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Description
The objectives of this study were to evaluate the in vitro and in vivo anti-tumor potential of the aqueous gall extract (G extract) from Limoniastrum guyonianum and to elucidate its immunological mechanisms, in part, by assessing its effects on the growth of transplanted tumors and the immune response in these tumor-bearing mice. Here, mice were inoculated with B16F10 mouse tumor cells and then treated intraperitoneally with G extract at 25 or 50. mg extract/kg. BW for 7, 14, or 21. days. At each timepoint, effects of the extract on the tumor growth, splenocytes proliferation, NK cell activity, and CTL activity among splenocytes isolated from the mice were measured. G extract-induced tumor growth inhibition was associated with characteristic apoptotic changes in the tumor cells, like nuclear condensation. In addition, the extract inhibited melanin synthesis and tyrosinase activity among melanoma cells in a concentration-related manner. G extract did not only significantly inhibit the growth of the transplantable tumor, but also remarkably increased splenocytes proliferation and both NK and CTL activities in tumor-bearing mice. The extract was also seen to have promoted lysosomal activity of host macrophages and gave rise to enhanced cellular anti-oxidant activity in several cell types in mice. © 2014 Elsevier Ltd.
Authors & Co-Authors
Krifa, Mounira
Tunisia, Monastir
Faculty of Pharmacy
Skandrani, Inès
Tunisia, Monastir
Faculty of Pharmacy
Pizzi, Antonio Li
France, Vandoeouvre-les-nancy
Laboratoire D'études et de Recherche Sur le Matériau Bois Lermab
Nasr, Nouha
Tunisia, Monastir
Faculty of Pharmacy
Ghedira, Zied
Tunisia, Monastir
Faculty of Pharmacy
Mustapha, Nadia
Tunisia, Monastir
Faculty of Pharmacy
Ghédira, Kamel
Tunisia, Monastir
Faculty of Pharmacy
Chékir-Ghédira, Leila
Tunisia, Monastir
Faculty of Pharmacy
Tunisia, Monastir
Faculté de Médecine Dentaire de Monastir
Statistics
Citations: 21
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.fct.2014.03.033
ISSN:
02786915
e-ISSN:
18736351
Research Areas
Cancer