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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Expansion of CD4
+
CD25
+
regulatory T cells by intravenous immunoglobulin: A critical factor in controlling experimental autoimmune encephalomyelitis
Blood, Volume 111, No. 2, Year 2008
Notification
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Description
The clinical use of intravenous immunoglobulin (IVIg) based on its immunomodulatory and anti-inflammatory potential remains an ongoing challenge. Fcγ receptor-mediated effects of IVIg, although well elucidated in certain pathologies, cannot entirely account for its proven benefit in several autoimmune disorders mediated by autoreactive T cells. In this study, we show that prophylactic infusion of IVIg prevents the development of experimental autoimmune encephalomyelitis (EAE), an accepted animal model for multiple sclerosis (MS). The protection was associated with peripheral increase in CD4+CD25+Foxp3+ regulatory T cell (Treg) numbers and function. The protection was Treg-mediated because IVIg failed to protect against EAE in mice that were depleted of the Treg population. Rather than inducing de novo generation from conventional T cells, IVIg had a direct effect on proliferation of natural Treg. In conclusion, our results highlight a novel mechanism of action of IVIg and provide a rationale to test the use of IVIg as an immunomodulatory tool to enhance Treg in early onset MS and other autoimmune and inflammatory conditions. © 2008 by The American Society of Hematology.
Authors & Co-Authors
Ephrem, Amal
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Université Paris Cité
Lebanon, Beirut
Université Libanaise
Chamat, Soulaïma S.
Lebanon, Beirut
Université Libanaise
Miquel, Catherine
France, Paris
Inserm
Fisson, Sylvain
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Université Paris Cité
Mouthon, Luc
France, Paris
Université Paris Cité
Caligiuri, Giuseppina
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Université Paris Cité
Delignat, Sandrine
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Université Paris Cité
Elluru, Sriramulu
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Université Paris Cité
Bayry, Jagadeesh
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Université Paris Cité
Lacroix-Desmazes, Sebastien
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Université Paris Cité
Cohen, José L.
France, Paris
Sorbonne Université
France, Paris
Cnrs Centre National de la Recherche Scientifique
Salomon, Benoit L.
France, Paris
Sorbonne Université
France, Paris
Cnrs Centre National de la Recherche Scientifique
Kazatchkine, Michel Daniel
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Université Paris Cité
Kaveri, Srini V.
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Université Paris Cité
Misra, Namita
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Université Paris Cité
France, Paris
Inserm
Statistics
Citations: 287
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.1182/blood-2007-03-079947
ISSN:
00064971
e-ISSN:
00064971
Study Design
Cross Sectional Study