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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Extent of liver inflammation in predicting response to interferon α & Ribavirin in chronic hepatitis C patients: a cohort study
BMC Gastroenterology, Volume 12, Article 71, Year 2012
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Description
Background: Liver inflammation due to HCV infection leads to fibrosis, which is an independent predictor of treatment response to interferon therapy in Chronic Hepatitis C (CHC) patients. This relationship has not been studied for liver inflammation on pretreatment liver biopsy and End of Treatment Response (ETR). ALT is a less invasive test than liver biopsy for measuring liver inflammation. Aim of this study was to compare ETR to Interferon α (recombinant Interferon) & Ribavirin in CHC patients having higher and lower grades of liver inflammation and to determine the diagnostic accuracy of pretreatment ALT for grades of liver inflammation.Methods: A retrospective cohort of 876 naïve CHC patients, who completed Interferon α & Ribavirin for 24 weeks, was studied for ETR. Pretreatment grade of inflammation on liver biopsy was taken as the exposure variable. It was classified as high if there was moderate or severe and low if there was minimal or mild. Multivariable logistic regression modeling was performed. Diagnostic accuracy of pretreatment ALT for liver inflammation grades was determined by computing Area Under the Receiver Operator Curve (AUROC).Results: Of all patients, 672 having diagnostic liver biopsy and ETR available were analyzed. Among them, 103 had high and 569 had low grades of liver inflammation. Mean age was 36.9 (SD 9.1) years, with patients with high grades being older than those with low grades inflammation (p = 0.03). High grades of liver inflammation was associated with ETR (RR 1.17, 95% CI 1.12-1.18) adjusting for age, Total Leukocyte count (TLC) and pretreatment levels of ALT, irrespective of liver fibrosis. This relation remained significant for 'bridging fibrosis and cirrhosis' and not for 'no' or 'portal fibrosis'. AUROC of pretreatment ALT for males and females was moderately accurate for severe inflammation compared to minimal inflammation and less accurate for high grades compared to low grades.Conclusions: ETR in patients with higher grades of liver inflammation was 17% higher than those with lower grades irrespective of fibrosis and 9% higher for bridging fibrosis and cirrhosis. Pretreatment ALT was moderately accurate for severe inflammation only on liver biopsy in both males and females. © 2012 Mirza et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Mirza, Shirin
Pakistan, Karachi
The Aga Khan University
Pakistan, Islamabad
Public Health Solutions Pakistan
Siddiqui, Amna R.
Pakistan, Karachi
The Aga Khan University
Saudi Arabia, Riyadh
College of Medicine
Hamid, Saeed Sadiq
Pakistan, Karachi
The Aga Khan University Hospital
Umar, Muhammad
Pakistan, Rawalpindi
Holy Family Hospital, Rawalpindi
Bashir, Shaheena
Canada, Hamilton
Mcmaster University
Statistics
Citations: 9
Authors: 5
Affiliations: 6
Identifiers
Doi:
10.1186/1471-230X-12-71
e-ISSN:
1471230X
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Female