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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens
iScience, Volume 26, No. 8, Article 107257, Year 2023
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Description
Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in response to infection. The protein site-specific glycosylation was characterized in plasma derived from well-defined controls and patients. We found 3862 unique features, of which we identified 463 distinct intact glycopeptides, that could be mapped to more than 30 different proteins. Statistical analyses were used to derive a glycopeptide signature that enabled significant differentiation between patients with a bacterial or viral infection. Furthermore, supported by a machine learning algorithm, we demonstrated the ability to identify the causative pathogens based on the distinctive host blood plasma glycopeptide signatures. These results illustrate that glycoproteomics holds enormous potential as an innovative approach to improve the interpretation of relevant biological changes in response to infection. © 2023 The Author(s)
Authors & Co-Authors
van der Flier, Michiel
Netherlands, Utrecht
University Medical Center Utrecht
van den Heuvel, Lambert P.W.J.
Netherlands, Nijmegen
Radboud University Medical Center
van de Kar, Nicole C.A.J.D.E.
Netherlands, Nijmegen
Radboud University Medical Center
Philipsen, Ria H.L.A.
Netherlands, Nijmegen
Radboud University Medical Center
Kaforou, Myrsini
United Kingdom, London
Imperial College London
Wright, Victoria J.
United Kingdom, London
Imperial College London
Herberg, Jethro Adam
United Kingdom, London
Imperial College London
Torres, Federico Martinón
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Levin, Michael L.
United Kingdom, London
Imperial College London
de Groot, Ronald C.A.
Netherlands, Nijmegen
Radboud University Medical Center
Lefeber, Dirk J.
Netherlands, Nijmegen
Radboud University Medical Center
de Jonge, Marien Isaäk
Netherlands, Nijmegen
Radboud University Medical Center
Abdulla, Amina F.
Unknown Affiliation
van Aerde, Koen J.
Unknown Affiliation
Agbeko, Rachel Sarah
Unknown Affiliation
Agyeman, Philipp Kwame Abayie
Unknown Affiliation
D'Alessandro, Umberto
Unknown Affiliation
Ali, Ladan
Unknown Affiliation
Alkema, Wynand B.L.
Unknown Affiliation
González, Fernando Álvez
Unknown Affiliation
Anderson, Suzanne T.B.
Unknown Affiliation
Farto, Cristina Balo
Unknown Affiliation
Barendregt, Anouk Marinke
Unknown Affiliation
Barral-Arca, Ruth
Unknown Affiliation
Castro, María Barreiro
Unknown Affiliation
Bath, David
Unknown Affiliation
Baumard, Lucas
Unknown Affiliation
Bello, Xabier
Unknown Affiliation
Bellos, Evangelos
Unknown Affiliation
Benesch, Martin
Unknown Affiliation
Ben García, Mirian
Unknown Affiliation
Berger, Christoph Tobias
Unknown Affiliation
van den Berg, J. Merlijn
Unknown Affiliation
Bibi, Sagida
Unknown Affiliation
Bidlingmaier, Christoph M.
Unknown Affiliation
Binder, Alexander
Unknown Affiliation
Bojang, Kalifa A.
Unknown Affiliation
von Both, Ulrich
Unknown Affiliation
Brengel-Pesce, Karen
Unknown Affiliation
Calvo-Bado, Leo A.
Unknown Affiliation
Carnota, Sandra
Unknown Affiliation
Carrol, Enitan D.
Unknown Affiliation
Carter, Michael J.
Unknown Affiliation
Cebey-López, Miriam
Unknown Affiliation
Ceesay, Samba
Unknown Affiliation
Cunnington, Aubrey J.
Unknown Affiliation
Currás-Tuala, María José
Unknown Affiliation
Danhauser, Katharina
Unknown Affiliation
Darboe, Saffiatou
Unknown Affiliation
Darnell, Sarah
Unknown Affiliation
De, Tisham
Unknown Affiliation
Dewez, Juan Emmanuel
Unknown Affiliation
Dudley, Julia R.
Unknown Affiliation
Suárez, Carlos Durán
Unknown Affiliation
Eber, Ernst
Unknown Affiliation
Eleftheriou, Irini
Unknown Affiliation
Emonts, Marieke
Unknown Affiliation
Feuchtinger, Tobias
Unknown Affiliation
Fidler, Katy J.
Unknown Affiliation
Fink, Colin G.
Unknown Affiliation
Van Furth, A. M.
Unknown Affiliation
Galassini, Rachel
Unknown Affiliation
Vicente, Luisa García
Unknown Affiliation
Gardovska, Dace Kh
Unknown Affiliation
Gõmez-Carballa, Alberto
Unknown Affiliation
Rial, Jose Gómez
Unknown Affiliation
Griese, Matthias
Unknown Affiliation
Gurung, Meeru
Unknown Affiliation
Habgood-Coote, Dominic
Unknown Affiliation
Hagedoorn, Nienke N.
Unknown Affiliation
Hamilton, Shea
Unknown Affiliation
Heininger, Ulrich
Unknown Affiliation
Hoggart, Clive J.
Unknown Affiliation
Hourmat, Sara
Unknown Affiliation
Jackson, Heather R.
Unknown Affiliation
Jennings, Rebecca J.
Unknown Affiliation
Jorgensen, Rikke
Unknown Affiliation
Kahlert, Christian R.
Unknown Affiliation
Kandasamy, Rama
Unknown Affiliation
Kim, Eunjung
Unknown Affiliation
Kohlfürst, Daniela S.
Unknown Affiliation
Kohlmaier, Benno
Unknown Affiliation
Kolberg, Laura
Unknown Affiliation
Kolnik, Mojca
Unknown Affiliation
Kuijpers, Taco W.
Unknown Affiliation
van der Kuip, Martijn
Unknown Affiliation
Iglesias, Pilar Leboráns
Unknown Affiliation
Lim, Emma J.
Unknown Affiliation
Lin, Naomi
Unknown Affiliation
Liu, Chingchuan
Unknown Affiliation
Lurz, Eberhard
Unknown Affiliation
Maconochie, Ian
Unknown Affiliation
Mallet, François
Unknown Affiliation
Martinón-Torres, Federico
Unknown Affiliation
Martin, Alexander James
Unknown Affiliation
Martinón-Sánchez, José María
Unknown Affiliation
Martinón-Torres, Nazareth
Unknown Affiliation
Menikou, Stephanie
Unknown Affiliation
van Mierlo, Gerard J.
Unknown Affiliation
Moll, Henriëtte A.
Unknown Affiliation
Mommert, Marine
Unknown Affiliation
Pérez, Belén Mosquera
Unknown Affiliation
Murdoch, David Roger
Unknown Affiliation
Mustafa, Sobia
Unknown Affiliation
Nichols, Samuel J.
Unknown Affiliation
Nijman, Ruud Gerard
Unknown Affiliation
Obihara, Charlie C.C.
Unknown Affiliation
Pachot, Alexandre
Unknown Affiliation
Pajkrt, Dasja
Unknown Affiliation
Pardo-Seco, Jacobo
Unknown Affiliation
Paulus, Stéphane C.
Unknown Affiliation
Paz, Ivonne Pena
Unknown Affiliation
Persand, Salina
Unknown Affiliation
Philipsen, Ria La
Unknown Affiliation
Pierce, Benjamin
Unknown Affiliation
Pischedda, Sara
Unknown Affiliation
Pokorn, Marko
Unknown Affiliation
Pollard, Andrew J.
Unknown Affiliation
Pósfay-Barbe, Klara Maria
Unknown Affiliation
Redondo Collazo, Lorenzo
Unknown Affiliation
Calle, Irene Rivero
Unknown Affiliation
Richmond, Vivien
Unknown Affiliation
Riedel, Thomas
Unknown Affiliation
Rodríguez-Tenreiro, Carmen
Unknown Affiliation
Romaine, Sam T.
Unknown Affiliation
Sagmeister, Manfred G.
Unknown Affiliation
Salas, Antonio
Unknown Affiliation
Schlapbach, Luregn J.
Unknown Affiliation
Secka, Fatou
Unknown Affiliation
Fernández, Sonia Serén
Unknown Affiliation
Shah, Priyen
Unknown Affiliation
Shen, Chingfen
Unknown Affiliation
Shrestha, Shrijana R.
Unknown Affiliation
D'Souza, Giselle
Unknown Affiliation
Sperl, Matthias
Unknown Affiliation
Schweintzger, Nina Alexandra
Unknown Affiliation
Stevens, Molly M.
Unknown Affiliation
Tavliavini, Emma
Unknown Affiliation
Till, Holger Karl H.
Unknown Affiliation
Trobisch, Andreas
Unknown Affiliation
Tsolia, Maria N.
Unknown Affiliation
Usuf, Effua Abigail
Unknown Affiliation
Vermont, Clementien L.
Unknown Affiliation
Vincek, Katarina
Unknown Affiliation
Voice, Marie
Unknown Affiliation
de Vries, Gabriella
Unknown Affiliation
Wang, Shihmin
Unknown Affiliation
Wilson, Clare M.
Unknown Affiliation
Yeung, Shunmay M.
Unknown Affiliation
Zavadska, Dace
Unknown Affiliation
Zaman, Syed M.A.
Unknown Affiliation
Zenz, Werner M.
Unknown Affiliation
Statistics
Authors: 152
Affiliations: 4
Identifiers
Doi:
10.1016/j.isci.2023.107257
ISSN:
25890042
Research Areas
Genetics And Genomics