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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants
Cell Host and Microbe, Volume 30, No. 1, Year 2022
Notification
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Description
Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1, and Delta-B.1.617.2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the antigenic structure of S, causing escape from natural or vaccine-induced immunity. Beta is particularly difficult to neutralize using serum induced by early pandemic SARS-CoV-2 strains and is most antigenically separated from Delta. To understand this, we generated 674 mAbs from Beta-infected individuals and performed a detailed structure-function analysis of the 27 most potent mAbs: one binding the spike N-terminal domain (NTD), the rest the receptor-binding domain (RBD). Two of these RBD-binding mAbs recognize a neutralizing epitope conserved between SARS-CoV-1 and -2, while 18 target mutated residues in Beta: K417N, E484K, and N501Y. There is a major response to N501Y, including a public IgVH4-39 sequence, with E484K and K417N also targeted. Recognition of these key residues underscores why serum from Beta cases poorly neutralizes early pandemic and Delta viruses. © 2021 The Author(s)
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8626228/bin/mmc1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8626228/bin/mmc2.pdf
Authors & Co-Authors
Liu, Chang
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Zhou, Daming
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Nutalai, Rungtiwa
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Duyvesteyn, Helen M.E.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Tuekprakhon, Aekkachai
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Ginn, Helen Mary
United Kingdom, Didcot
Diamond Light Source
Dejnirattisai, Wanwisa
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Supasa, Piyada
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Mentzer, Alexander J.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Wang, Beibei
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Zhao, Yuguang
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Skelly, Dónal Thomas
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
Chen, Rita E.
United States, St. Louis
Washington University School of Medicine in St. Louis
Johnson, Síle Ann
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
Ritter, Thomas G.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Mason, Chris J.B.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Malik, Tariq
United Kingdom, London
Public Health England
Temperton, Nigel James
United Kingdom, Chatham
Medway School of Pharmacy
Paterson, Neil G.
United Kingdom, Didcot
Diamond Light Source
Williams, Mark A.
United Kingdom, Didcot
Diamond Light Source
Hall, David Richard
United Kingdom, Didcot
Diamond Light Source
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
University of Oxford
Fry, Elizabeth E.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Diamond, Michael S.
United States, St. Louis
Washington University School of Medicine in St. Louis
Mongkolsapaya, Juthathip
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Thailand, Nakhon Pathom
Mahidol University
Ren, Jingshan
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Stuart, David Ian
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Didcot
Diamond Light Source
Screaton, Gavin Robert
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Statistics
Citations: 35
Authors: 28
Affiliations: 8
Identifiers
Doi:
10.1016/j.chom.2021.11.013
ISSN:
19313128