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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Myoblast transplantation between monozygotic twin girl carriers of Duchenne muscular dystrophy
Neuromuscular Disorders, Volume 3, No. 5-6, Year 1993
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Description
Monozygotic twin girls, both carriers of Duchenne muscular dystrophy, only one a severe symptomatic carrier and the other asymptomatic due to opposite lyonization, were studied. Myoblast clones were obtained from a muscle biopsy of the asymptomatic carrier. PCR amplification showed that most (94%) of these clones produced normal dystrophin mRNA. Roughly 704 million myoblasts were produced from 119 clones. These myoblasts were transplanted into the extensor carpi radialis (ECR) and in the biceps of one arm of the manifesting carrier while the other arm acted as the control. The strength of the patient was evaluated in a series of pre- and post-tests and a biopsy was obtained about 1 yr after the transplantation. The myoblast injections produced a significant force gain (12%-31%) in wrist extension but no force gain for elbow flexion. Muscle biopsies on the injected and control muscles obtained 1 yr after the injections showed only a small increase in the number of dystrophin positive fibers and the presence of numerous small type II fibers. The small beneficial effect of this transplantation cannot be attributed to immune problems, the donor and the recipient being identical twins, but may be due to a low level of spontaneous muscle regeneration. © 1993.
Authors & Co-Authors
Bouchard, Jean Pierre
Canada, Quebec
Université Laval
Collin, Huguette
France, Paris
Inserm
Rouche, Andreée
France, Paris
Inserm
Tomé, Fernando M.S.
Unknown Affiliation
Fardeau, Michael
Unknown Affiliation
Statistics
Citations: 82
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/0960-8966(93)90121-Y
ISSN:
09608966
Research Areas
Disability
Health System And Policy
Participants Gender
Female