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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Persistence of K103N-containing HIV-1 variants after single-dose nevirapine for prevention of HIV-1 mother-to-child transmission
Journal of Infectious Diseases, Volume 195, No. 5, Year 2007
Notification
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Description
K103N-containing human immunodeficiency virus (HIV)-1 variants are selected in some women who receive single-dose (SD) nevirapine (NVP) for prevention of HIV-1 mother-infant transmission. We examined the persistence of K103N in women who received SD NVP prophylaxis. K103N was detected using the LigAmp assay (assay cutoff, 0.5% K103N). K103N was detected at 6-8 weeks in 60 (41.7%) of 144 women. Fading (lack of detection) of K103N was documented in 16 women by 2 years, 43 women by 3 years, and 55 women by 4 and 5 years. Slower fading was independently associated with HIV-1 subtype (D>A) and higher pre-NVP viral load. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Flys, Tamara S.
United States, Baltimore
Johns Hopkins School of Medicine
Donnell, Deborah J.
United States, Seattle
Fred Hutchinson Cancer Research Center
Mwatha, Anthony K.
United States, Seattle
Fred Hutchinson Cancer Research Center
Nakabiito, Clemensia
Uganda, Kampala
Makerere University
Musoke, Philippa Martha
Uganda, Kampala
Makerere University
Mmiro, Francis A.
Uganda, Kampala
Makerere University
Jackson, J. Brooks
United States, Baltimore
Johns Hopkins School of Medicine
Guay, Laura A.
United States, Baltimore
Johns Hopkins School of Medicine
Eshleman, Susan H.
United States, Baltimore
Johns Hopkins School of Medicine
United States, Baltimore
Johns Hopkins Medical Institutions
Statistics
Citations: 77
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1086/511433
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health
Participants Gender
Female