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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The ACTN3 R577X polymorphism in east and west African athletes
Medicine and Science in Sports and Exercise, Volume 39, No. 11, Year 2007
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Description
PURPOSE: To determine the frequency of the ACTN3 R577X polymorphism (functional R allele and nonfunctional X allele) in a variety of African populations and to examine its influence on the success of elite East African endurance runners and West African sprinters. METHODS: The R577X polymorphism was genotyped in 198 Ethiopian controls and 76 elite Ethiopian endurance athletes, 158 Kenyan controls and 284 elite Kenyan endurance runners, and 60 Nigerian controls and 62 elite Nigerian power athletes. Statistical analyses were performed by exact tests of population differentiation, using Arlequin, version 3. Analyses were carried out using 1 × 10 Markov chain steps, and 1 × 10 dememorization steps. RESULTS: The frequency of the X allele was extremely low among Kenyans and Nigerians (∼1% homozygosity) and higher in Ethiopians (∼11% homozygosity). The low baseline frequencies of the three populations tested mean that any associations with sprint performance would likely be obscured. In Ethiopians, where baseline levels of 577XX were about 11%, there was no increased frequency in the endurance athletes. CONCLUSION: Our data suggest that α-actinin-3 deficiency is not a major influence on performance in African athletes. ©2007The American College of Sports Medicine.
Authors & Co-Authors
Yang, Nan
Australia, Sydney
The Children's Hospital at Westmead
MacArthur, Daniel G.
Australia, Sydney
The Children's Hospital at Westmead
Wolde, Bezabeh
Ethiopia, Addis Ababa
Kotebe University of Education
Onywera, Vincent Ochieng
Kenya, Nairobi
Kenyatta University
Boit, M. K.
Kenya, Nairobi
Kenyatta University
Lau, Sau Yin Mary Ann
Australia, Sydney
The Children's Hospital at Westmead
Wilson, Richard H.
United Kingdom, Glasgow
University of Glasgow
Scott, Robert A.
United Kingdom, Glasgow
University of Glasgow
Pitsiladis, Yannis Paul
United Kingdom, Glasgow
University of Glasgow
North, Kathryn N.
Australia, Sydney
The Children's Hospital at Westmead
Australia, Sydney
Faculty of Medicine and Health
Australia
Neurogenetics Research Unit
Statistics
Citations: 135
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1249/mss.0b013e31814844c9
ISSN:
01959131
e-ISSN:
15300315
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study